P2CS-Web

Two-component systems, rebuilt for exploration

Gene detail

FN517_RS00985

Histidine kinase, Unorthodox

Escherichia coli · GCF_902164025

Open genomeOpen selected clusterRefSeqUniProt
ClassHKTypeUnorthodoxLength1197 aaTM0ValidatedNoCompleteYesContextpaired
Gene IDGCF_902164025#FN517_RS00985Stable P2CS identifier used across views.
GenomeGCF_902164025Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Selected clusterHKOC_0161111Run 6 · 440 sequences · id 100% · cov 80%
External referencesWP_001546059.1 · A0A7I0L024 · MIST4 FN517_RS00985RefSeq · UniProt · MIST4

Domain signature

Compact overview inferred from the domain field

PBPbHisKAHATPase_cResponse_regHpt
Protein length1197 aaLength used to scale native and Biotite-like views.
Annotated domains66 with usable coordinates.
Domain coverage796 / 1197 aa (66.5%)Merged over positioned domains only.
Domain description2 PBPb,1 HisKA,1 HATPase_c,1 Response_reg,1 HptSummary string stored in the genes table.
Signal peptideUnavailableNo TMPRED prediction file matched this gene.
Transmembrane helicesUnavailableConfigure [protein_features] tmpred_root_dir to enable this annotation.
Complete domain annotations
Domain view
NativeBiotite-like
Native P2CS viewFrontend rendering from the parsed domain string and TMPRED protein features.
1 aa1197 aa
PBPb: 73-276 aa (204 aa)1PBPb: 304-519 aa (216 aa)2HisKA: 711-777 aa (67 aa)3HATPase_c: 825-938 aa (114 aa)4Response_reg: 961-1070 aa (110 aa)5Hpt: 1104-1188 aa (85 aa)6
Domain-by-domain annotation6 items
1 PBPb#1
73-276 aa · 204 aa · 17.0% of protein
Raw tokenPBPb:73:0.00000000000000209:276:209:219
2 PBPb#2
304-519 aa · 216 aa · 18.0% of protein
Raw tokenPBPb:304:1.9e-38:519:223:219
3 HisKA#3
711-777 aa · 67 aa · 5.6% of protein
Raw tokenHisKA:711:3.19e-16:777:67:64
4 HATPase_c#4
825-938 aa · 114 aa · 9.5% of protein
Raw tokenHATPase_c:825:5.58e-31:938:114:109
5 Response_reg#5
961-1070 aa · 110 aa · 9.2% of protein
Raw tokenResponse_reg:961:2.03e-39:1070:110:111
6 Hpt#6
1104-1188 aa · 85 aa · 7.1% of protein
Raw tokenHpt:1104:0.000000404:1188:85:84
  • Raw architecture: PBPb:73:0.00000000000000209:276:209:219#PBPb:304:1.9e-38:519:223:219#HisKA:711:3.19e-16:777:67:64#HATPase_c:825:5.58e-31:938:114:109#Response_reg:961:2.03e-39:1070:110:111#Hpt:1104:0.000000404:1188:85:84
  • Domain description: 2 PBPb,1 HisKA,1 HATPase_c,1 Response_reg,1 Hpt
  • TM description: N/A
  • TMPRED source: No TMPRED file loaded
  • TMPRED segments: N/A
  • Complete: Yes

Context mapping

Resolved via p2cs_tcs_context.db when a locus tag match exists

Context labelpairedGCF_902164025::NZ_CABHBW010000001.1::G00005
Group size22 locus tags listed below.
HK / RR1 / 1Counts resolved for the local TCS neighborhood.
Context span218318-222530Genomic interval covered by the local TCS group.
Identifiers
RefSeq proteinWP_001546059.1
Context group IDGCF_902164025::NZ_CABHBW010000001.1::G00005
Context members
FN517_RS00985FN517_RS00990
Partner locus tags
FN517_RS00985FN517_RS00990
Partner protein IDs
WP_001546059.1WP_000991370.1

External references

Resolved via p2cs_annexes.db when the RefSeq protein is present in the annex table

RefSeqWP_001546059.1Primary protein accession used for annex mappings.
UniProt accessionA0A7I0L024Primary UniProt accession resolved in the annex database.
UniProt IDA0A7I0L024_ECO25Display identifier provided by UniProt.
GO / PubMed4 / 0Unique GO terms and literature references available below.
Reference hubs
Open RefSeqOpen UniProt accession
GO terms
GO:0005886GO:0005524GO:0009927GO:0000155

Genomic coordinates

Resolved via p2cs_tcs_context.db when the current locus tag is present in the local context table

Current locus tagFN517_RS00985Primary locus identifier stored in the genes table.
Old locus tagUnavailableNo previous locus tag available for this gene.
Contig / repliconNZ_CABHBW010000001.1Sequence record reported by the local genomic context database.
Genomic interval218 318-221 911 nt3 594 nt · Reverse (-)
StrandReverse (-)Strand sign follows the local context database convention.
Local TCS group span218 318-222 530 ntGCF_902164025::NZ_CABHBW010000001.1::G00005
Quick actions
Open genomeSearch genes in genome

Local neighborhood

Graphical neighborhood resolved from the local TCS context group on the current contig

GCF_902164025::NZ_CABHBW010000001.1::G00005
Graphic view
CompactBiotite-like
Zoom
Full windowFocus gene

Compact keeps a quick overview. Biotite-like switches to a coordinate-aware biological layout with strand and zoom.

Context labelpairedNeighborhood members are ordered by genomic coordinates.
Contig / repliconNZ_CABHBW010000001.1All displayed genes belong to this local TCS context.
Neighborhood span218 318-222 530 nt4 213 nt
Members21 current focus gene
Local TCS group mapArrow direction follows strand. The current gene is highlighted with a stronger outline.
218 318 nt222 530 nt
+-FN517_RS00985FN517_RS00990
Neighborhood gene cards

2 genes in the current local neighborhood.

FN517_RS00990GCF_902164025#FN517_RS00990
RRunclassified

221 916-222 530 nt · Reverse (-)

RefSeq WP_000991370.1
Open gene

Clusters

CD-HIT memberships and selected cluster details for the current gene class

Available memberships1 cluster
HKOC_0161111HK
Run 6440 sequencesid 100%cov 80%
PFAM SBP_bac_3 + SBP_bac_3 + HisKA + HATPase_c + Response_reg
Representative GCF_000326345#WK3_RS10820
Selected clusterHKOC_0161111Run 6 · HK · 440 sequences
Representative sequenceGCF_000326345#WK3_RS10820Use this link to inspect the representative gene detail.
PFAM architectureSBP_bac_3 + SBP_bac_3 + HisKA + HATPase_c + Response_reg5 domains in the representative PFAM annotation.
Open in cluster searchOpen representative gene

PFAM architecture for HKOC_0161111

Simplified PFAM architecture for HKOC_0161111

PFAM domain coverage: 719 / 1197 aa (60.1%)

1 aa1197 aa
SBP_bac_3: 63-276 aaSBP_bac_3SBP_bac_3: 306-520 aaSBP_bac_3HisKA: 711-777 aaHisKAHATPase_c: 825-937 aaHATPase_cResponse_reg: 961-1070 aaResponse_reg
SBP_bac_3SBP_bac_3HisKAHATPase_cResponse_reg
  • Simplified architecture: SBP_bac_3 + SBP_bac_3 + HisKA + HATPase_c + Response_reg
  • Raw architecture: SBP_bac_3[63-276] | SBP_bac_3[306-520] | HisKA[711-777] | HATPase_c[825-937] | Response_reg[961-1070]
  • Domain count: 5
  • Matched identifier: HKOC_0161111
  • Positioned domains: SBP_bac_3 63-276 ; SBP_bac_3 306-520 ; HisKA 711-777 ; HATPase_c 825-937 ; Response_reg 961-1070
Cluster members and taxonomy
Visualization
SankeyMember list

Representative gene: GCF_000326345#WK3_RS10820

Sankey plot built from the taxonomy of all members in the selected cluster.

Genome taxonomy

Unknown

Taxonomy recordUnknownTaxon ID 562 · GCF_902164025
Assembly25964_2#194 · Scaffoldhaploid
Genome composition5 252 367 bp · 50,0% GCEscherichia coli
Signal transduction countsGenes 66 · HK 32 · RR 34CheA 1 · PP 0
Ranked taxonomy7 ranked levels available
SuperkingdomBacteriaKingdomPseudomonadatiPhylumPseudomonadotaClassGammaproteobacteriaOrderEnterobacteralesFamilyEnterobacteriaceaeGenusEscherichia
Lineage path7 lineage nodes
1Bacteria2Pseudomonadati3Pseudomonadota4Gammaproteobacteria5Enterobacterales6Enterobacteriaceae7Escherichia
Open genomeSearch genes in genomeSearch HK genesNCBI assembly files

Related genes

Preview from the same derived genome key

10 preview genes

This panel keeps a short preview on the gene page. Use the genome search to inspect the complete list.

Search all genome genesSearch HK genes
FN517_RS00190GCF_902164025#FN517_RS00190
RRunclassified

RR gene found in the same genome-level preview.

Open gene
FN517_RS00990GCF_902164025#FN517_RS00990
RRunclassified

RR gene found in the same genome-level preview.

Open gene
FN517_RS01650GCF_902164025#FN517_RS01650
RRunclassified

RR gene found in the same genome-level preview.

Open gene