P2CS-Web
Two-component systems, rebuilt for exploration
P2CS
Two-component systems, rebuilt for genome-scale exploration.
P2CS-Web revisits the historical P2CS resource to make two-component system exploration easier to read, filter, and share across genomes, lineages, and protein records.
The current application already connects real SQLite datasets, preserves stable biological identifiers, and exposes genome-first and gene-first entry points that prepare the transition toward P2CS_2026.
Indexed genomes
Genome-level entries already exposed through browse genomes
392 075
A direct entry point to taxonomic browsing, counts, and genome detail pages.
Listed proteins
Gene records currently available through the versioned API
25 663 653
Stable identifiers remain central so genome and gene pages stay cross-linkable.
Histidine kinases
Protein records filtered live from the legacy genes table
12 517 906
Sensor-side components can already be explored from gene and genome views.
Clusters
2 931 715
Criteria: 100% identity, 80% coverage.
Response regulators
Companion class surfaced for downstream decision workflows
12 774 395
These counts are computed from the same API used by the detailed gene lists.
Clusters
2 479 169
Criteria: 100% identity, 80% coverage.
Family Distributions
RR and HK families at a glance
Choose which classes to display and switch between several Plotly chart types. Click a family to open a filtered gene list. Pie charts stay the default view.
Loading family distributions
Real RR and HK distributions are loading in the background
The overview is already available. Charts will appear as soon as the aggregated family counts finish loading.
What P2CS-Web is for
A modern scientific entry point built from the public utility of the legacy site
P2CS-Web keeps the historical strengths of P2CS: browsing by genomes and lineages, navigating from protein classes to detailed records, and keeping identifiers stable enough for scientific reuse.
- Genome-centric exploration for species, taxonomic paths, and TCS counts.
- Gene-centric inspection for annotations, domains, and cross-links back to the source genome.
- Preparation for richer comparison, search, and P2CS_2026 integration.
How to start exploring
Begin broad, then refine toward the biological object you need
- Start with `browse genomes` to scan lineages and choose a genome of interest.
- Switch between the precomputed Krona panorama and the live taxonomy wheel when selecting genomes.
- Open genome detail pages to inspect counts and jump into matching proteins.
- Use gene detail pages to verify annotations and follow related records.
Browse by lineage
Start from genomes, species names, and taxonomic paths
Use the shared browse page to move from a broad panorama to exact lineage filters, then open individual genome records.
Inspect a genome
Move from taxonomic context to TCS composition
Genome pages summarize lineage, protein-class counts, and gene-level drill-down from the same stable genome identifiers.
Inspect a protein
Jump directly to a representative gene record
Gene detail pages preserve biological identifiers while exposing annotations, domains, related genes, and links back to the parent genome.