1 His_kinase#1
358-437 aa · 80 aa · 14.3% of protein
Raw token
His_kinase:358:2.6e-27:437:80:80P2CS-Web
Two-component systems, rebuilt for exploration
Gene detail
EFME4453_RS12140
Histidine kinase, Classic
Enterococcus faecium E4453 · GCF_000239095
ClassHKTypeClassicLength561 aaTM0ValidatedNoCompleteYesContextpaired
Gene IDGCF_000239095#EFME4453_RS12140Stable P2CS identifier used across views.
GenomeGCF_000239095Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales; Enterococcaceae; Enterococcus
Domain signature
Compact overview inferred from the domain field
His_kinaseHATPase_c
Protein length561 aaLength used to scale native and Biotite-like views.
Annotated domains22 with usable coordinates.
Domain coverage175 / 561 aa (31.2%)Merged over positioned domains only.
Domain description1 His_kinase,1 HATPase_cSummary string stored in the genes table.
Signal peptideUnavailableNo TMPRED prediction file matched this gene.
Transmembrane helicesUnavailableConfigure [protein_features] tmpred_root_dir to enable this annotation.
Complete domain annotations
Native P2CS viewFrontend rendering from the parsed domain string and TMPRED protein features.
1 aa561 aa
Domain-by-domain annotation2 items
2 HATPase_c#2
457-551 aa · 95 aa · 16.9% of protein
Raw token
HATPase_c:457:0.000000000127:551:105:109- Raw architecture: His_kinase:358:2.6e-27:437:80:80#HATPase_c:457:0.000000000127:551:105:109
- Domain description: 1 His_kinase,1 HATPase_c
- TM description: N/A
- TMPRED source: No TMPRED file loaded
- TMPRED segments: N/A
- Complete: Yes
Context mapping
Resolved via p2cs_tcs_context.db when a locus tag match exists
Context labelpairedGCF_000239095::NZ_AEDZ01000328.1::G00001
Group size22 locus tags listed below.
HK / RR1 / 1Counts resolved for the local TCS neighborhood.
Context span31605-34845Genomic interval covered by the local TCS group.
Identifiers
Old locus tagEfmE4453_1117RefSeq proteinWP_002323121.1
Context group ID
GCF_000239095::NZ_AEDZ01000328.1::G00001Context members
EFME4453_RS12140EFME4453_RS15740
Partner locus tags
EFME4453_RS12140EFME4453_RS15740
Partner old locus tags
EfmE4453_1117EfmE4453_1118
Partner protein IDs
External references
Resolved via p2cs_annexes.db when the RefSeq protein is present in the annex table
No UniProt / GO / PubMed mapping was found for WP_002323121.1.
Genomic coordinates
Resolved via p2cs_tcs_context.db when the current locus tag is present in the local context table
Current locus tagEFME4453_RS12140Primary locus identifier stored in the genes table.
Old locus tagEfmE4453_1117Legacy locus tag recovered from the local context mapping.
Contig / repliconNZ_AEDZ01000328.1Sequence record reported by the local genomic context database.
Genomic interval31 605-33 290 nt1 686 nt · Reverse (-)
StrandReverse (-)Strand sign follows the local context database convention.
Local TCS group span31 605-34 845 ntGCF_000239095::NZ_AEDZ01000328.1::G00001
Quick actions
Local neighborhood
Graphical neighborhood resolved from the local TCS context group on the current contig
GCF_000239095::NZ_AEDZ01000328.1::G00001Graphic view
Compact keeps a quick overview. Biotite-like switches to a coordinate-aware biological layout with strand and zoom.
Context labelpairedNeighborhood members are ordered by genomic coordinates.
Contig / repliconNZ_AEDZ01000328.1All displayed genes belong to this local TCS context.
Neighborhood span31 605-34 845 nt3 241 nt
Members21 current focus gene
Local TCS group mapArrow direction follows strand. The current gene is highlighted with a stronger outline.
31 605 nt34 845 nt
Neighborhood gene cards
2 genes in the current local neighborhood.
EFME4453_RS12140GCF_000239095#EFME4453_RS12140
HKClassicCurrent focus
31 605-33 290 nt · Reverse (-)
EFME4453_RS15740GCF_000239095#EFME4453_RS15740
RRunclassified
33 337-34 845 nt · Reverse (-)
Clusters
CD-HIT memberships and selected cluster details for the current gene class
Available memberships1 cluster
Representative sequenceGCF_000239095#EFME4453_RS12140The current gene is the representative for this cluster.
PFAM architectureHis_kinase + HATPase_c2 domains in the representative PFAM annotation.
PFAM architecture for HKOC_1253863
Simplified PFAM architecture for HKOC_1253863
PFAM domain coverage: 175 / 561 aa (31.2%)
1 aa561 aa
His_kinaseHATPase_c
- Simplified architecture: His_kinase + HATPase_c
- Raw architecture: His_kinase[359-437] | HATPase_c[456-551]
- Domain count: 2
- Matched identifier: HKOC_1253863
- Positioned domains: His_kinase 359-437 ; HATPase_c 456-551
Cluster members and taxonomy
Representative gene: GCF_000239095#EFME4453_RS12140
Sankey plot built from the taxonomy of all members in the selected cluster.
Genome taxonomy
Unknown
Taxonomy recordUnknownTaxon ID 873 127 · GCF_000239095
AssemblyASM23909v2 · Contighaploid
Genome composition2 819 308 bp · 38,0% GCEnterococcus faecium E4453
Signal transduction countsGenes 36 · HK 17 · RR 19CheA 0 · PP 0
Ranked taxonomy7 ranked levels available
SuperkingdomBacteriaKingdomBacillatiPhylumBacillotaClassBacilliOrderLactobacillalesFamilyEnterococcaceaeGenusEnterococcus
Lineage path7 lineage nodes
1Bacteria2Bacillati3Bacillota4Bacilli5Lactobacillales6Enterococcaceae7Enterococcus
Related genes
Preview from the same derived genome key