Gene detail

HMPREF9541_RS10370

Histidine kinase, Classic

Escherichia coli MS 116-1 · GCF_000164475

ClassHKTypeClassicLength420 aaTM0ValidatedNoCompleteYesContextpaired
Gene IDGCF_000164475#HMPREF9541_RS10370Stable P2CS identifier used across views.
GenomeGCF_000164475Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Selected clusterHKOC_2267276Run 6 · 3159 sequences · id 100% · cov 80%
External referencesWP_001329690.1 · B7MZV3 · MIST4 HMPREF9541_RS10370RefSeq · UniProt · MIST4

Domain signature

Compact overview inferred from the domain field

PocRHis_kinaseHATPase_c
Protein length420 aaLength used to scale native and Biotite-like views.
Annotated domains33 with usable coordinates.
Domain coverage353 / 420 aa (84.0%)Merged over positioned domains only.
Domain description1 PocR,1 His_kinase,1 HATPase_cSummary string stored in the genes table.
Signal peptideUnavailableNo TMPRED prediction file matched this gene.
Transmembrane helicesUnavailableConfigure [protein_features] tmpred_root_dir to enable this annotation.
Complete domain annotations
Native P2CS viewFrontend rendering from the parsed domain string and TMPRED protein features.
1 aa420 aa
PocR: 20-183 aa (164 aa)1His_kinase: 215-295 aa (81 aa)2HATPase_c: 312-419 aa (108 aa)3
Domain-by-domain annotation3 items
1 PocR#1
20-183 aa · 164 aa · 39.0% of protein
Raw tokenPocR:20:7.56e-55:183:164:162
2 His_kinase#2
215-295 aa · 81 aa · 19.3% of protein
Raw tokenHis_kinase:215:7.55e-33:295:81:80
3 HATPase_c#3
312-419 aa · 108 aa · 25.7% of protein
Raw tokenHATPase_c:312:0.0000000663:419:113:109
  • Raw architecture: PocR:20:7.56e-55:183:164:162#His_kinase:215:7.55e-33:295:81:80#HATPase_c:312:0.0000000663:419:113:109
  • Domain description: 1 PocR,1 His_kinase,1 HATPase_c
  • TM description: N/A
  • TMPRED source: No TMPRED file loaded
  • TMPRED segments: N/A
  • Complete: Yes

Context mapping

Resolved via p2cs_tcs_context.db when a locus tag match exists

Context labelpairedGCF_000164475::NZ_GG773443.1::G00020
Group size22 locus tags listed below.
HK / RR1 / 1Counts resolved for the local TCS neighborhood.
Context span17085-19419Genomic interval covered by the local TCS group.
Identifiers
Old locus tagHMPREF9541_02849RefSeq proteinWP_001329690.1
Context group IDGCF_000164475::NZ_GG773443.1::G00020
Context members
HMPREF9541_RS10370HMPREF9541_RS10365
Partner locus tags
HMPREF9541_RS10370HMPREF9541_RS10365
Partner old locus tags
HMPREF9541_02849HMPREF9541_02850
Partner protein IDs

External references

Resolved via p2cs_annexes.db when the RefSeq protein is present in the annex table

RefSeqWP_001329690.1Primary protein accession used for annex mappings.
UniProt accessionB7MZV3Primary UniProt accession resolved in the annex database.
UniProt IDB7MZV3_ECO81Display identifier provided by UniProt.
GO / PubMed2 / 1Unique GO terms and literature references available below.
PubMed

Genomic coordinates

Resolved via p2cs_tcs_context.db when the current locus tag is present in the local context table

Current locus tagHMPREF9541_RS10370Primary locus identifier stored in the genes table.
Old locus tagHMPREF9541_02849Legacy locus tag recovered from the local context mapping.
Contig / repliconNZ_GG773443.1Sequence record reported by the local genomic context database.
Genomic interval17 085-18 347 nt1 263 nt · Forward (+)
StrandForward (+)Strand sign follows the local context database convention.
Local TCS group span17 085-19 419 ntGCF_000164475::NZ_GG773443.1::G00020

Local neighborhood

Graphical neighborhood resolved from the local TCS context group on the current contig

GCF_000164475::NZ_GG773443.1::G00020

Compact keeps a quick overview. Biotite-like switches to a coordinate-aware biological layout with strand and zoom.

Context labelpairedNeighborhood members are ordered by genomic coordinates.
Contig / repliconNZ_GG773443.1All displayed genes belong to this local TCS context.
Neighborhood span17 085-19 419 nt2 335 nt
Members21 current focus gene
Local TCS group mapArrow direction follows strand. The current gene is highlighted with a stronger outline.
17 085 nt19 419 nt
Neighborhood gene cards

2 genes in the current local neighborhood.

HMPREF9541_RS10365GCF_000164475#HMPREF9541_RS10365
RRunclassified

18 364-19 419 nt · Forward (+)

Old locus HMPREF9541_02850RefSeq WP_000494233.1

Clusters

CD-HIT memberships and selected cluster details for the current gene class

Selected clusterHKOC_2267276Run 6 · HK · 3159 sequences
Representative sequenceGCF_000014845#APECO1_RS23805Use this link to inspect the representative gene detail.
PFAM architecturePocR + His_kinase + HATPase_c3 domains in the representative PFAM annotation.

PFAM architecture for HKOC_2267276

Simplified PFAM architecture for HKOC_2267276

PFAM domain coverage: 350 / 420 aa (83.3%)

1 aa420 aa
PocR: 20-182 aaPocRHis_kinase: 215-295 aaHis_kinaseHATPase_c: 313-418 aaHATPase_c
PocRHis_kinaseHATPase_c
  • Simplified architecture: PocR + His_kinase + HATPase_c
  • Raw architecture: PocR[20-182] | His_kinase[215-295] | HATPase_c[313-418]
  • Domain count: 3
  • Matched identifier: HKOC_2267276
  • Positioned domains: PocR 20-182 ; His_kinase 215-295 ; HATPase_c 313-418
Cluster members and taxonomy
Visualization

Representative gene: GCF_000014845#APECO1_RS23805

Sankey plot built from the taxonomy of all members in the selected cluster.

Genome taxonomy

Unknown

Taxonomy recordUnknownTaxon ID 749 538 · GCF_000164475
AssemblyASM16447v1 · Scaffoldhaploid
Genome composition4 863 660 bp · 50,5% GCEscherichia coli MS 116-1
Signal transduction countsGenes 64 · HK 31 · RR 33CheA 1 · PP 0
Ranked taxonomy7 ranked levels available
SuperkingdomBacteriaKingdomPseudomonadatiPhylumPseudomonadotaClassGammaproteobacteriaOrderEnterobacteralesFamilyEnterobacteriaceaeGenusEscherichia
Lineage path7 lineage nodes
1Bacteria2Pseudomonadati3Pseudomonadota4Gammaproteobacteria5Enterobacterales6Enterobacteriaceae7Escherichia

Related genes

Preview from the same derived genome key