Gene detail

E1153_RS06405

Histidine kinase, Classic

Clostridioides difficile · GCF_900688555

ClassHKTypeClassicLength850 aaTM0ValidatedNoCompleteYesContexthexad
Gene IDGCF_900688555#E1153_RS06405Stable P2CS identifier used across views.
GenomeGCF_900688555Bacteria; Bacillati; Bacillota; Clostridia; Peptostreptococcales; Peptostreptococcaceae; Clostridioides
Selected clusterHKOC_0490346Run 6 · 1 sequences · id 100% · cov 80% · representative
External referencesWP_235666859.1 · MIST4 E1153_RS06405RefSeq · MIST4

Domain signature

Compact overview inferred from the domain field

KdpDGAF_3HisKAHATPase_c
Protein length850 aaLength used to scale native and Biotite-like views.
Annotated domains44 with usable coordinates.
Domain coverage484 / 850 aa (56.9%)Merged over positioned domains only.
Domain description1 KdpD,1 GAF_3,1 HisKA,1 HATPase_cSummary string stored in the genes table.
Signal peptideUnavailableNo TMPRED prediction file matched this gene.
Transmembrane helicesUnavailableConfigure [protein_features] tmpred_root_dir to enable this annotation.
Complete domain annotations
Native P2CS viewFrontend rendering from the parsed domain string and TMPRED protein features.
1 aa850 aa
KdpD: 2-180 aa (179 aa)1GAF_3: 483-606 aa (124 aa)2HisKA: 626-693 aa (68 aa)3HATPase_c: 737-849 aa (113 aa)4
Domain-by-domain annotation4 items
1 KdpD#1
2-180 aa · 179 aa · 21.1% of protein
Raw tokenKdpD:2:2.06e-111:180:179:210
2 GAF_3#2
483-606 aa · 124 aa · 14.6% of protein
Raw tokenGAF_3:483:0.0000057:606:129:129
3 HisKA#3
626-693 aa · 68 aa · 8.0% of protein
Raw tokenHisKA:626:0.00000000000661:693:68:64
4 HATPase_c#4
737-849 aa · 113 aa · 13.3% of protein
Raw tokenHATPase_c:737:2.75e-30:849:113:109
  • Raw architecture: KdpD:2:2.06e-111:180:179:210#GAF_3:483:0.0000057:606:129:129#HisKA:626:0.00000000000661:693:68:64#HATPase_c:737:2.75e-30:849:113:109
  • Domain description: 1 KdpD,1 GAF_3,1 HisKA,1 HATPase_c
  • TM description: N/A
  • TMPRED source: No TMPRED file loaded
  • TMPRED segments: N/A
  • Complete: Yes

Context mapping

Resolved via p2cs_tcs_context.db when a locus tag match exists

Context labelhexadGCF_900688555::NZ_CAADAX010000003.1::G00017
Group size66 locus tags listed below.
HK / RR3 / 3Counts resolved for the local TCS neighborhood.
Context span123966-130815Genomic interval covered by the local TCS group.
Identifiers
Old locus tagSAMEA1402364_01287RefSeq proteinWP_235666859.1
Context group IDGCF_900688555::NZ_CAADAX010000003.1::G00017
Context members
E1153_RS06405E1153_RS06410E1153_RS06415E1153_RS06420E1153_RS06425E1153_RS06430
Partner locus tags
E1153_RS06405E1153_RS06410E1153_RS06415E1153_RS06420E1153_RS06425E1153_RS06430
Partner old locus tags
SAMEA1402364_01287SAMEA1402364_01288SAMEA1402364_01289SAMEA1402364_01290SAMEA1402364_01291SAMEA1402364_01292

External references

Resolved via p2cs_annexes.db when the RefSeq protein is present in the annex table

No UniProt / GO / PubMed mapping was found for WP_235666859.1.

Genomic coordinates

Resolved via p2cs_tcs_context.db when the current locus tag is present in the local context table

Current locus tagE1153_RS06405Primary locus identifier stored in the genes table.
Old locus tagSAMEA1402364_01287Legacy locus tag recovered from the local context mapping.
Contig / repliconNZ_CAADAX010000003.1Sequence record reported by the local genomic context database.
Genomic interval123 966-126 518 nt2 553 nt · Forward (+)
StrandForward (+)Strand sign follows the local context database convention.
Local TCS group span123 966-130 815 ntGCF_900688555::NZ_CAADAX010000003.1::G00017

Local neighborhood

Graphical neighborhood resolved from the local TCS context group on the current contig

GCF_900688555::NZ_CAADAX010000003.1::G00017

Compact keeps a quick overview. Biotite-like switches to a coordinate-aware biological layout with strand and zoom.

Context labelhexadNeighborhood members are ordered by genomic coordinates.
Contig / repliconNZ_CAADAX010000003.1All displayed genes belong to this local TCS context.
Neighborhood span123 966-130 815 nt6 850 nt
Members61 current focus gene
Local TCS group mapArrow direction follows strand. The current gene is highlighted with a stronger outline.
123 966 nt130 815 nt
Neighborhood gene cards

6 genes in the current local neighborhood.

E1153_RS06405GCF_900688555#E1153_RS06405
HKClassicCurrent focus

123 966-126 518 nt · Forward (+)

Old locus SAMEA1402364_01287RefSeq WP_235666859.1
E1153_RS06410GCF_900688555#E1153_RS06410
RROmpR

126 552-127 250 nt · Forward (+)

Old locus SAMEA1402364_01288RefSeq WP_003439430.1
E1153_RS06415GCF_900688555#E1153_RS06415
HKClassic

127 359-128 207 nt · Forward (+)

Old locus SAMEA1402364_01289RefSeq WP_021376879.1
E1153_RS06420GCF_900688555#E1153_RS06420
RROmpR

128 241-128 939 nt · Forward (+)

Old locus SAMEA1402364_01290RefSeq WP_003439430.1
E1153_RS06425GCF_900688555#E1153_RS06425
HKClassic

129 118-130 083 nt · Forward (+)

Old locus SAMEA1402364_01291RefSeq WP_235666860.1
E1153_RS06430GCF_900688555#E1153_RS06430
RROmpR

130 117-130 815 nt · Forward (+)

Old locus SAMEA1402364_01292RefSeq WP_003439430.1

Clusters

CD-HIT memberships and selected cluster details for the current gene class

Selected clusterHKOC_0490346Run 6 · HK · 1 sequences
Representative sequenceGCF_900688555#E1153_RS06405The current gene is the representative for this cluster.
PFAM architectureKdpD + DUF4118 + HisKA + HATPase_c4 domains in the representative PFAM annotation.

PFAM architecture for HKOC_0490346

Simplified PFAM architecture for HKOC_0490346

PFAM domain coverage: 464 / 850 aa (54.6%)

1 aa850 aa
KdpD: 2-180 aaKdpDDUF4118: 359-464 aaDUF4118HisKA: 626-693 aaHisKAHATPase_c: 738-848 aaHATPase_c
KdpDDUF4118HisKAHATPase_c
  • Simplified architecture: KdpD + DUF4118 + HisKA + HATPase_c
  • Raw architecture: KdpD[2-180] | DUF4118[359-464] | HisKA[626-693] | HATPase_c[738-848]
  • Domain count: 4
  • Matched identifier: HKOC_0490346
  • Positioned domains: KdpD 2-180 ; DUF4118 359-464 ; HisKA 626-693 ; HATPase_c 738-848
Cluster members and taxonomy
Visualization

Representative gene: GCF_900688555#E1153_RS06405

Sankey plot built from the taxonomy of all members in the selected cluster.

Genome taxonomy

Unknown

Taxonomy recordUnknownTaxon ID 1 496 · GCF_900688555
Assembly7614_7#46 · Scaffoldhaploid
Genome composition4 416 792 bp · 28,5% GCClostridioides difficile
Signal transduction countsGenes 113 · HK 52 · RR 60CheA 1 · PP 1
Ranked taxonomy7 ranked levels available
SuperkingdomBacteriaKingdomBacillatiPhylumBacillotaClassClostridiaOrderPeptostreptococcalesFamilyPeptostreptococcaceaeGenusClostridioides
Lineage path7 lineage nodes
1Bacteria2Bacillati3Bacillota4Clostridia5Peptostreptococcales6Peptostreptococcaceae7Clostridioides

Related genes

Preview from the same derived genome key