Gene detail

SIK61_RS12280

Histidine kinase, Classic

Clostridioides difficile · GCF_033840955

ClassHKTypeClassicLength662 aaTM0ValidatedNoCompleteYesContextorphan
Gene IDGCF_033840955#SIK61_RS12280Stable P2CS identifier used across views.
GenomeGCF_033840955Bacteria; Bacillati; Bacillota; Clostridia; Peptostreptococcales; Peptostreptococcaceae; Clostridioides
Selected clusterHKOC_0387803Run 6 · 385 sequences · id 100% · cov 80%
External referencesWP_320062503.1 · MIST4 SIK61_RS12280RefSeq · MIST4

Domain signature

Compact overview inferred from the domain field

PAS_9HisKAHATPase_c
Protein length662 aaLength used to scale native and Biotite-like views.
Annotated domains33 with usable coordinates.
Domain coverage284 / 662 aa (42.9%)Merged over positioned domains only.
Domain description1 PAS_9,1 HisKA,1 HATPase_cSummary string stored in the genes table.
Signal peptideUnavailableNo TMPRED prediction file matched this gene.
Transmembrane helicesUnavailableConfigure [protein_features] tmpred_root_dir to enable this annotation.
Complete domain annotations
Native P2CS viewFrontend rendering from the parsed domain string and TMPRED protein features.
1 aa662 aa
PAS_9: 279-379 aa (101 aa)1HisKA: 405-476 aa (72 aa)2HATPase_c: 523-633 aa (111 aa)3
Domain-by-domain annotation3 items
1 PAS_9#1
279-379 aa · 101 aa · 15.3% of protein
Raw tokenPAS_9:279:0.0000273:379:101:102
2 HisKA#2
405-476 aa · 72 aa · 10.9% of protein
Raw tokenHisKA:405:0.00000000000000483:476:72:64
3 HATPase_c#3
523-633 aa · 111 aa · 16.8% of protein
Raw tokenHATPase_c:523:3.64e-32:633:111:109
  • Raw architecture: PAS_9:279:0.0000273:379:101:102#HisKA:405:0.00000000000000483:476:72:64#HATPase_c:523:3.64e-32:633:111:109
  • Domain description: 1 PAS_9,1 HisKA,1 HATPase_c
  • TM description: N/A
  • TMPRED source: No TMPRED file loaded
  • TMPRED segments: N/A
  • Complete: Yes

Context mapping

Resolved via p2cs_tcs_context.db when a locus tag match exists

Context labelorphanGCF_033840955::NZ_JAWXRW010000308.1::G00014
Group size11 locus tag listed below.
HK / RR1 / 0Counts resolved for the local TCS neighborhood.
Context span2218-4206Genomic interval covered by the local TCS group.
Identifiers
Old locus tagSIK61_12265RefSeq proteinWP_320062503.1
Context group IDGCF_033840955::NZ_JAWXRW010000308.1::G00014
Context members
SIK61_RS12280
Partner locus tags
SIK61_RS12280
Partner old locus tags
SIK61_12265
Partner protein IDs

External references

Resolved via p2cs_annexes.db when the RefSeq protein is present in the annex table

No UniProt / GO / PubMed mapping was found for WP_320062503.1.

Genomic coordinates

Resolved via p2cs_tcs_context.db when the current locus tag is present in the local context table

Current locus tagSIK61_RS12280Primary locus identifier stored in the genes table.
Old locus tagSIK61_12265Legacy locus tag recovered from the local context mapping.
Contig / repliconNZ_JAWXRW010000308.1Sequence record reported by the local genomic context database.
Genomic interval2 218-4 206 nt1 989 nt · Reverse (-)
StrandReverse (-)Strand sign follows the local context database convention.
Local TCS group span2 218-4 206 ntGCF_033840955::NZ_JAWXRW010000308.1::G00014

Local neighborhood

Graphical neighborhood resolved from the local TCS context group on the current contig

GCF_033840955::NZ_JAWXRW010000308.1::G00014

Compact keeps a quick overview. Biotite-like switches to a coordinate-aware biological layout with strand and zoom.

Context labelorphanNeighborhood members are ordered by genomic coordinates.
Contig / repliconNZ_JAWXRW010000308.1All displayed genes belong to this local TCS context.
Neighborhood span2 218-4 206 nt1 989 nt
Members11 current focus gene
Local TCS group mapArrow direction follows strand. The current gene is highlighted with a stronger outline.
2 218 nt4 206 nt
Neighborhood gene cards

1 gene in the current local neighborhood.

SIK61_RS12280GCF_033840955#SIK61_RS12280
HKClassicCurrent focus

2 218-4 206 nt · Reverse (-)

Old locus SIK61_12265RefSeq WP_320062503.1

Clusters

CD-HIT memberships and selected cluster details for the current gene class

Selected clusterHKOC_0387803Run 6 · HK · 385 sequences
Representative sequenceGCF_000003215#QAC_RS0212590Use this link to inspect the representative gene detail.
PFAM architecturePAS_8 + PAS_9 + HisKA + HATPase_c4 domains in the representative PFAM annotation.

PFAM architecture for HKOC_0387803

Simplified PFAM architecture for HKOC_0387803

PFAM domain coverage: 340 / 912 aa (37.3%)

1 aa912 aa
PAS_8: 303-355 aaPAS_8PAS_9: 529-632 aaPAS_9HisKA: 655-726 aaHisKAHATPase_c: 773-883 aaHATPase_c
PAS_8PAS_9HisKAHATPase_c
  • Simplified architecture: PAS_8 + PAS_9 + HisKA + HATPase_c
  • Raw architecture: PAS_8[303-355] | PAS_9[529-632] | HisKA[655-726] | HATPase_c[773-883]
  • Domain count: 4
  • Matched identifier: HKOC_0387803
  • Positioned domains: PAS_8 303-355 ; PAS_9 529-632 ; HisKA 655-726 ; HATPase_c 773-883
Cluster members and taxonomy
Visualization

Representative gene: GCF_000003215#QAC_RS0212590

Sankey plot built from the taxonomy of all members in the selected cluster.

Genome taxonomy

Unknown

Taxonomy recordUnknownTaxon ID 1 496 · GCF_033840955
AssemblyASM3384095v1 · Contighaploid
Genome composition3 759 897 bp · 29,0% GCClostridioides difficile
Signal transduction countsGenes 86 · HK 36 · RR 47CheA 1 · PP 3
Ranked taxonomy7 ranked levels available
SuperkingdomBacteriaKingdomBacillatiPhylumBacillotaClassClostridiaOrderPeptostreptococcalesFamilyPeptostreptococcaceaeGenusClostridioides
Lineage path7 lineage nodes
1Bacteria2Bacillati3Bacillota4Clostridia5Peptostreptococcales6Peptostreptococcaceae7Clostridioides

Related genes

Preview from the same derived genome key