Gene detail

EC970246_RS08665

Histidine kinase, Classic

Escherichia coli 97.0246 · GCF_000194215

ClassHKTypeClassicLength486 aaTM0ValidatedNoCompleteYesContextpaired
Gene IDGCF_000194215#EC970246_RS08665Stable P2CS identifier used across views.
GenomeGCF_000194215Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Selected clusterHKOC_1567203Run 6 · 40 sequences · id 100% · cov 80% · representative
External referencesWP_000735399.1 · A0A8E0FKZ7 · MIST4 EC970246_RS08665RefSeq · UniProt · MIST4

Domain signature

Compact overview inferred from the domain field

PhoQ_SensorHAMPHisKAHATPase_c
Protein length486 aaLength used to scale native and Biotite-like views.
Annotated domains44 with usable coordinates.
Domain coverage411 / 486 aa (84.6%)Merged over positioned domains only.
Domain description1 PhoQ_Sensor,1 HAMP,1 HisKA,1 HATPase_cSummary string stored in the genes table.
Signal peptideUnavailableNo TMPRED prediction file matched this gene.
Transmembrane helicesUnavailableConfigure [protein_features] tmpred_root_dir to enable this annotation.
Complete domain annotations
Native P2CS viewFrontend rendering from the parsed domain string and TMPRED protein features.
1 aa486 aa
PhoQ_Sensor: 10-189 aa (180 aa)1HAMP: 195-263 aa (69 aa)2HisKA: 272-330 aa (59 aa)3HATPase_c: 374-476 aa (103 aa)4
Domain-by-domain annotation4 items
1 PhoQ_Sensor#1
10-189 aa · 180 aa · 37.0% of protein
Raw tokenPhoQ_Sensor:10:2.72e-113:189:180:179
2 HAMP#2
195-263 aa · 69 aa · 14.2% of protein
Raw tokenHAMP:195:0.00000000396:263:69:69
3 HisKA#3
272-330 aa · 59 aa · 12.1% of protein
Raw tokenHisKA:272:0.00000046:330:59:64
4 HATPase_c#4
374-476 aa · 103 aa · 21.2% of protein
Raw tokenHATPase_c:374:1.34e-21:476:105:109
  • Raw architecture: PhoQ_Sensor:10:2.72e-113:189:180:179#HAMP:195:0.00000000396:263:69:69#HisKA:272:0.00000046:330:59:64#HATPase_c:374:1.34e-21:476:105:109
  • Domain description: 1 PhoQ_Sensor,1 HAMP,1 HisKA,1 HATPase_c
  • TM description: N/A
  • TMPRED source: No TMPRED file loaded
  • TMPRED segments: N/A
  • Complete: Yes

Context mapping

Resolved via p2cs_tcs_context.db when a locus tag match exists

Context labelpairedGCF_000194215::NZ_AEZJ02000030.1::G00010
Group size22 locus tags listed below.
HK / RR1 / 1Counts resolved for the local TCS neighborhood.
Context span14846-16977Genomic interval covered by the local TCS group.
Identifiers
Old locus tagEC970246_1983RefSeq proteinWP_000735399.1
Context group IDGCF_000194215::NZ_AEZJ02000030.1::G00010
Context members
EC970246_RS08665EC970246_RS08660
Partner locus tags
EC970246_RS08665EC970246_RS08660
Partner old locus tags
EC970246_1983EC970246_1984
Partner protein IDs

External references

Resolved via p2cs_annexes.db when the RefSeq protein is present in the annex table

RefSeqWP_000735399.1Primary protein accession used for annex mappings.
UniProt accessionA0A8E0FKZ7Primary UniProt accession resolved in the annex database.
UniProt IDA0A8E0FKZ7_ECOLXDisplay identifier provided by UniProt.
GO / PubMed5 / 0Unique GO terms and literature references available below.

Genomic coordinates

Resolved via p2cs_tcs_context.db when the current locus tag is present in the local context table

Current locus tagEC970246_RS08665Primary locus identifier stored in the genes table.
Old locus tagEC970246_1983Legacy locus tag recovered from the local context mapping.
Contig / repliconNZ_AEZJ02000030.1Sequence record reported by the local genomic context database.
Genomic interval14 846-16 306 nt1 461 nt · Reverse (-)
StrandReverse (-)Strand sign follows the local context database convention.
Local TCS group span14 846-16 977 ntGCF_000194215::NZ_AEZJ02000030.1::G00010

Local neighborhood

Graphical neighborhood resolved from the local TCS context group on the current contig

GCF_000194215::NZ_AEZJ02000030.1::G00010

Compact keeps a quick overview. Biotite-like switches to a coordinate-aware biological layout with strand and zoom.

Context labelpairedNeighborhood members are ordered by genomic coordinates.
Contig / repliconNZ_AEZJ02000030.1All displayed genes belong to this local TCS context.
Neighborhood span14 846-16 977 nt2 132 nt
Members21 current focus gene
Local TCS group mapArrow direction follows strand. The current gene is highlighted with a stronger outline.
14 846 nt16 977 nt
Neighborhood gene cards

2 genes in the current local neighborhood.

EC970246_RS08660GCF_000194215#EC970246_RS08660
RROmpR

16 306-16 977 nt · Reverse (-)

Old locus EC970246_1984RefSeq WP_001265481.1

Clusters

CD-HIT memberships and selected cluster details for the current gene class

Selected clusterHKOC_1567203Run 6 · HK · 40 sequences
Representative sequenceGCF_000194215#EC970246_RS08665The current gene is the representative for this cluster.
PFAM architecturePhoQ_Sensor + HATPase_c2 domains in the representative PFAM annotation.

PFAM architecture for HKOC_1567203

Simplified PFAM architecture for HKOC_1567203

PFAM domain coverage: 280 / 486 aa (57.6%)

1 aa486 aa
PhoQ_Sensor: 10-188 aaPhoQ_SensorHATPase_c: 375-475 aaHATPase_c
PhoQ_SensorHATPase_c
  • Simplified architecture: PhoQ_Sensor + HATPase_c
  • Raw architecture: PhoQ_Sensor[10-188] | HATPase_c[375-475]
  • Domain count: 2
  • Matched identifier: HKOC_1567203
  • Positioned domains: PhoQ_Sensor 10-188 ; HATPase_c 375-475
Cluster members and taxonomy
Visualization

Representative gene: GCF_000194215#EC970246_RS08665

Sankey plot built from the taxonomy of all members in the selected cluster.

Genome taxonomy

Unknown

Taxonomy recordUnknownTaxon ID 869 670 · GCF_000194215
AssemblyASM19421v2 · Contighaploid
Genome composition5 497 467 bp · 50,5% GCEscherichia coli 97.0246
Signal transduction countsGenes 60 · HK 29 · RR 31CheA 1 · PP 0
Ranked taxonomy7 ranked levels available
SuperkingdomBacteriaKingdomPseudomonadatiPhylumPseudomonadotaClassGammaproteobacteriaOrderEnterobacteralesFamilyEnterobacteriaceaeGenusEscherichia
Lineage path7 lineage nodes
1Bacteria2Pseudomonadati3Pseudomonadota4Gammaproteobacteria5Enterobacterales6Enterobacteriaceae7Escherichia

Related genes

Preview from the same derived genome key