Gene detail

EC53638_RS03170

Histidine kinase, Classic

Escherichia coli 53638 · GCF_000167915

ClassHKTypeClassicLength894 aaTM0ValidatedNoCompleteYesContextpaired
Gene IDGCF_000167915#EC53638_RS03170Stable P2CS identifier used across views.
GenomeGCF_000167915Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Selected clusterHKOC_0419603Run 6 · 54 sequences · id 100% · cov 80% · representative
External referencesWP_001300359.1 · A0A377FCW7 · MIST4 EC53638_RS03170RefSeq · UniProt · MIST4

Domain signature

Compact overview inferred from the domain field

KdpDGAF_3HisKAHATPase_c
Protein length894 aaLength used to scale native and Biotite-like views.
Annotated domains44 with usable coordinates.
Domain coverage502 / 894 aa (56.2%)Merged over positioned domains only.
Domain description1 KdpD,1 GAF_3,1 HisKA,1 HATPase_cSummary string stored in the genes table.
Signal peptideUnavailableNo TMPRED prediction file matched this gene.
Transmembrane helicesUnavailableConfigure [protein_features] tmpred_root_dir to enable this annotation.
Complete domain annotations
Native P2CS viewFrontend rendering from the parsed domain string and TMPRED protein features.
1 aa894 aa
KdpD: 21-230 aa (210 aa)1GAF_3: 527-644 aa (118 aa)2HisKA: 664-730 aa (67 aa)3HATPase_c: 774-880 aa (107 aa)4
Domain-by-domain annotation4 items
1 KdpD#1
21-230 aa · 210 aa · 23.5% of protein
Raw tokenKdpD:21:4.66e-143:230:210:210
2 GAF_3#2
527-644 aa · 118 aa · 13.2% of protein
Raw tokenGAF_3:527:0.00000000000395:644:130:129
3 HisKA#3
664-730 aa · 67 aa · 7.5% of protein
Raw tokenHisKA:664:0.000000000000277:730:68:64
4 HATPase_c#4
774-880 aa · 107 aa · 12.0% of protein
Raw tokenHATPase_c:774:9.43e-31:880:107:109
  • Raw architecture: KdpD:21:4.66e-143:230:210:210#GAF_3:527:0.00000000000395:644:130:129#HisKA:664:0.000000000000277:730:68:64#HATPase_c:774:9.43e-31:880:107:109
  • Domain description: 1 KdpD,1 GAF_3,1 HisKA,1 HATPase_c
  • TM description: N/A
  • TMPRED source: No TMPRED file loaded
  • TMPRED segments: N/A
  • Complete: Yes

Context mapping

Resolved via p2cs_tcs_context.db when a locus tag match exists

Context labelpairedGCF_000167915::NZ_AAKB02000001.1::G00004
Group size22 locus tags listed below.
HK / RR1 / 1Counts resolved for the local TCS neighborhood.
Context span585370-588728Genomic interval covered by the local TCS group.
Identifiers
Old locus tagEc53638_0618RefSeq proteinWP_001300359.1
Context group IDGCF_000167915::NZ_AAKB02000001.1::G00004
Context members
EC53638_RS03170EC53638_RS03175
Partner locus tags
EC53638_RS03170EC53638_RS03175
Partner old locus tags
Ec53638_0618Ec53638_0619
Partner protein IDs

External references

Resolved via p2cs_annexes.db when the RefSeq protein is present in the annex table

RefSeqWP_001300359.1Primary protein accession used for annex mappings.
UniProt accessionA0A377FCW7Primary UniProt accession resolved in the annex database.
UniProt IDA0A377FCW7_ECOLXDisplay identifier provided by UniProt.
GO / PubMed5 / 0Unique GO terms and literature references available below.

Genomic coordinates

Resolved via p2cs_tcs_context.db when the current locus tag is present in the local context table

Current locus tagEC53638_RS03170Primary locus identifier stored in the genes table.
Old locus tagEc53638_0618Legacy locus tag recovered from the local context mapping.
Contig / repliconNZ_AAKB02000001.1Sequence record reported by the local genomic context database.
Genomic interval585 370-588 054 nt2 685 nt · Forward (+)
StrandForward (+)Strand sign follows the local context database convention.
Local TCS group span585 370-588 728 ntGCF_000167915::NZ_AAKB02000001.1::G00004

Local neighborhood

Graphical neighborhood resolved from the local TCS context group on the current contig

GCF_000167915::NZ_AAKB02000001.1::G00004

Compact keeps a quick overview. Biotite-like switches to a coordinate-aware biological layout with strand and zoom.

Context labelpairedNeighborhood members are ordered by genomic coordinates.
Contig / repliconNZ_AAKB02000001.1All displayed genes belong to this local TCS context.
Neighborhood span585 370-588 728 nt3 359 nt
Members21 current focus gene
Local TCS group mapArrow direction follows strand. The current gene is highlighted with a stronger outline.
585 370 nt588 728 nt
Neighborhood gene cards

2 genes in the current local neighborhood.

EC53638_RS03170GCF_000167915#EC53638_RS03170
HKClassicCurrent focus

585 370-588 054 nt · Forward (+)

Old locus Ec53638_0618RefSeq WP_001300359.1
EC53638_RS03175GCF_000167915#EC53638_RS03175
RROmpR

588 051-588 728 nt · Forward (+)

Old locus Ec53638_0619RefSeq WP_000186076.1

Clusters

CD-HIT memberships and selected cluster details for the current gene class

Selected clusterHKOC_0419603Run 6 · HK · 54 sequences
Representative sequenceGCF_000167915#EC53638_RS03170The current gene is the representative for this cluster.
PFAM architectureKdpD + DUF4118 + GAF_3 + HisKA + HATPase_c5 domains in the representative PFAM annotation.

PFAM architecture for HKOC_0419603

Simplified PFAM architecture for HKOC_0419603

PFAM domain coverage: 607 / 894 aa (67.9%)

1 aa894 aa
KdpD: 22-230 aaKdpDDUF4118: 403-508 aaDUF4118GAF_3: 527-644 aaGAF_3HisKA: 664-730 aaHisKAHATPase_c: 776-882 aaHATPase_c
KdpDDUF4118GAF_3HisKAHATPase_c
  • Simplified architecture: KdpD + DUF4118 + GAF_3 + HisKA + HATPase_c
  • Raw architecture: KdpD[22-230] | DUF4118[403-508] | GAF_3[527-644] | HisKA[664-730] | HATPase_c[776-882]
  • Domain count: 5
  • Matched identifier: HKOC_0419603
  • Positioned domains: KdpD 22-230 ; DUF4118 403-508 ; GAF_3 527-644 ; HisKA 664-730 ; HATPase_c 776-882
Cluster members and taxonomy
Visualization

Representative gene: GCF_000167915#EC53638_RS03170

Sankey plot built from the taxonomy of all members in the selected cluster.

Genome taxonomy

Unknown

Taxonomy recordUnknownTaxon ID 344 610 · GCF_000167915
AssemblyASM16791v2 · Contighaploid
Genome composition5 371 790 bp · 51,0% GCEscherichia coli 53638
Signal transduction countsGenes 62 · HK 29 · RR 33CheA 1 · PP 0
Ranked taxonomy7 ranked levels available
SuperkingdomBacteriaKingdomPseudomonadatiPhylumPseudomonadotaClassGammaproteobacteriaOrderEnterobacteralesFamilyEnterobacteriaceaeGenusEscherichia
Lineage path7 lineage nodes
1Bacteria2Pseudomonadati3Pseudomonadota4Gammaproteobacteria5Enterobacterales6Enterobacteriaceae7Escherichia

Related genes

Preview from the same derived genome key