Gene detail

b2469

Histidine kinase, Classic

Escherichia coli str. K-12 substr. MG1655 · GCF_000005845

ClassHKTypeClassicLength566 aaTM0ValidatedNoCompleteYesContextorphan
Gene IDGCF_000005845#b2469Stable P2CS identifier used across views.
GenomeGCF_000005845Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Selected clusterHKOC_1228909Run 6 · 8700 sequences · id 100% · cov 80% · representative
External referencesNP_416964.1 · MIST4 b2469RefSeq · MIST4

Domain signature

Compact overview inferred from the domain field

PilJHAMPHisKA_3HATPase_c
Protein length566 aaLength used to scale native and Biotite-like views.
Annotated domains44 with usable coordinates.
Domain coverage324 / 566 aa (57.2%)Merged over positioned domains only.
Domain description1 PilJ,1 HAMP,1 HisKA_3,1 HATPase_cSummary string stored in the genes table.
Signal peptideUnavailableNo TMPRED prediction file matched this gene.
Transmembrane helicesUnavailableConfigure [protein_features] tmpred_root_dir to enable this annotation.
Complete domain annotations
Native P2CS viewFrontend rendering from the parsed domain string and TMPRED protein features.
1 aa566 aa
PilJ: 31-125 aa (95 aa)1HAMP: 150-224 aa (75 aa)2HisKA_3: 361-424 aa (64 aa)3HATPase_c: 467-556 aa (90 aa)4
Domain-by-domain annotation4 items
1 PilJ#1
31-125 aa · 95 aa · 16.8% of protein
Raw tokenPilJ:31:3.47e-17:125:111:112
2 HAMP#2
150-224 aa · 75 aa · 13.3% of protein
Raw tokenHAMP:150:0.00000000000128:224:75:69
3 HisKA_3#3
361-424 aa · 64 aa · 11.3% of protein
Raw tokenHisKA_3:361:2.27e-17:424:64:68
4 HATPase_c#4
467-556 aa · 90 aa · 15.9% of protein
Raw tokenHATPase_c:467:2.09e-19:556:105:109
  • Raw architecture: PilJ:31:3.47e-17:125:111:112#HAMP:150:0.00000000000128:224:75:69#HisKA_3:361:2.27e-17:424:64:68#HATPase_c:467:2.09e-19:556:105:109
  • Domain description: 1 PilJ,1 HAMP,1 HisKA_3,1 HATPase_c
  • TM description: N/A
  • TMPRED source: No TMPRED file loaded
  • TMPRED segments: N/A
  • Complete: Yes

Context mapping

Resolved via p2cs_tcs_context.db when a locus tag match exists

Context labelorphanGCF_000005845::NC_000913.3::G00024
Group size11 locus tag listed below.
HK / RR1 / 0Counts resolved for the local TCS neighborhood.
Context span2585731-2587431Genomic interval covered by the local TCS group.
Context group IDGCF_000005845::NC_000913.3::G00024
Context members
b2469
Partner locus tags
b2469
Partner protein IDs

External references

Resolved via p2cs_annexes.db when the RefSeq protein is present in the annex table

No UniProt / GO / PubMed mapping was found for NP_416964.1.

Genomic coordinates

Resolved via p2cs_tcs_context.db when the current locus tag is present in the local context table

Current locus tagb2469Primary locus identifier stored in the genes table.
Old locus tagUnavailableNo previous locus tag available for this gene.
Contig / repliconNC_000913.3Sequence record reported by the local genomic context database.
Genomic interval2 585 731-2 587 431 nt1 701 nt · Forward (+)
StrandForward (+)Strand sign follows the local context database convention.
Local TCS group span2 585 731-2 587 431 ntGCF_000005845::NC_000913.3::G00024

Local neighborhood

Graphical neighborhood resolved from the local TCS context group on the current contig

GCF_000005845::NC_000913.3::G00024

Compact keeps a quick overview. Biotite-like switches to a coordinate-aware biological layout with strand and zoom.

Context labelorphanNeighborhood members are ordered by genomic coordinates.
Contig / repliconNC_000913.3All displayed genes belong to this local TCS context.
Neighborhood span2 585 731-2 587 431 nt1 701 nt
Members11 current focus gene
Local TCS group mapArrow direction follows strand. The current gene is highlighted with a stronger outline.
2 585 731 nt2 587 431 nt
Neighborhood gene cards

1 gene in the current local neighborhood.

b2469GCF_000005845#b2469
HKClassicCurrent focus

2 585 731-2 587 431 nt · Forward (+)

RefSeq NP_416964.1

Clusters

CD-HIT memberships and selected cluster details for the current gene class

Selected clusterHKOC_1228909Run 6 · HK · 8700 sequences
Representative sequenceGCF_000005845#b2469The current gene is the representative for this cluster.
PFAM architecturePilJ + HAMP + HisKA_3 + HATPase_c4 domains in the representative PFAM annotation.

PFAM architecture for HKOC_1228909

Simplified PFAM architecture for HKOC_1228909

PFAM domain coverage: 302 / 566 aa (53.4%)

1 aa566 aa
PilJ: 32-127 aaPilJHAMP: 172-223 aaHAMPHisKA_3: 361-424 aaHisKA_3HATPase_c: 467-556 aaHATPase_c
PilJHAMPHisKA_3HATPase_c
  • Simplified architecture: PilJ + HAMP + HisKA_3 + HATPase_c
  • Raw architecture: PilJ[32-127] | HAMP[172-223] | HisKA_3[361-424] | HATPase_c[467-556]
  • Domain count: 4
  • Matched identifier: HKOC_1228909
  • Positioned domains: PilJ 32-127 ; HAMP 172-223 ; HisKA_3 361-424 ; HATPase_c 467-556
Cluster members and taxonomy
Visualization

Representative gene: GCF_000005845#b2469

Sankey plot built from the taxonomy of all members in the selected cluster.

Genome taxonomy

Unknown

Taxonomy recordUnknownTaxon ID 511 145 · GCF_000005845
AssemblyASM584v2 · Complete Genomereference genome · haploid
Genome composition4 641 652 bp · 51,0% GCEscherichia coli str. K-12 substr. MG1655
Signal transduction countsGenes 63 · HK 31 · RR 32CheA 2 · PP 0
Ranked taxonomy7 ranked levels available
SuperkingdomBacteriaKingdomPseudomonadatiPhylumPseudomonadotaClassGammaproteobacteriaOrderEnterobacteralesFamilyEnterobacteriaceaeGenusEscherichia
Lineage path7 lineage nodes
1Bacteria2Pseudomonadati3Pseudomonadota4Gammaproteobacteria5Enterobacterales6Enterobacteriaceae7Escherichia

Related genes

Preview from the same derived genome key