1 HAMP#1
192-259 aa · 68 aa · 11.2% of protein
Raw token
HAMP:192:0.00000000101:259:69:69P2CS-Web
Two-component systems, rebuilt for exploration
Gene detail
b2219
Histidine kinase, Classic
Escherichia coli str. K-12 substr. MG1655 · GCF_000005845
ClassHKTypeClassicLength608 aaTM0ValidatedNoCompleteYesContextpaired
Gene IDGCF_000005845#b2219Stable P2CS identifier used across views.
GenomeGCF_000005845Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Domain signature
Compact overview inferred from the domain field
HAMPPASHisKAHATPase_c
Protein length608 aaLength used to scale native and Biotite-like views.
Annotated domains44 with usable coordinates.
Domain coverage346 / 608 aa (56.9%)Merged over positioned domains only.
Domain description1 HAMP,1 PAS,1 HisKA,1 HATPase_cSummary string stored in the genes table.
Signal peptideUnavailableNo TMPRED prediction file matched this gene.
Transmembrane helicesUnavailableConfigure [protein_features] tmpred_root_dir to enable this annotation.
Complete domain annotations
Native P2CS viewFrontend rendering from the parsed domain string and TMPRED protein features.
1 aa608 aa
Domain-by-domain annotation4 items
2 PAS#2
265-370 aa · 106 aa · 17.4% of protein
Raw token
PAS:265:4.35e-21:370:110:1133 HisKA#3
389-452 aa · 64 aa · 10.5% of protein
Raw token
HisKA:389:0.00000000000000195:452:64:644 HATPase_c#4
495-602 aa · 108 aa · 17.8% of protein
Raw token
HATPase_c:495:5.1e-27:602:112:109- Raw architecture: HAMP:192:0.00000000101:259:69:69#PAS:265:4.35e-21:370:110:113#HisKA:389:0.00000000000000195:452:64:64#HATPase_c:495:5.1e-27:602:112:109
- Domain description: 1 HAMP,1 PAS,1 HisKA,1 HATPase_c
- TM description: N/A
- TMPRED source: No TMPRED file loaded
- TMPRED segments: N/A
- Complete: Yes
Context mapping
Resolved via p2cs_tcs_context.db when a locus tag match exists
Context labelpairedGCF_000005845::NC_000913.3::G00021
Group size22 locus tags listed below.
HK / RR1 / 1Counts resolved for the local TCS neighborhood.
Context span2320043-2323251Genomic interval covered by the local TCS group.
Identifiers
Context group ID
GCF_000005845::NC_000913.3::G00021Context members
b2219b2220
Partner locus tags
b2219b2220
Partner protein IDs
External references
Resolved via p2cs_annexes.db when the RefSeq protein is present in the annex table
No UniProt / GO / PubMed mapping was found for NP_416723.1.
Genomic coordinates
Resolved via p2cs_tcs_context.db when the current locus tag is present in the local context table
Current locus tagb2219Primary locus identifier stored in the genes table.
Old locus tagUnavailableNo previous locus tag available for this gene.
Contig / repliconNC_000913.3Sequence record reported by the local genomic context database.
Genomic interval2 320 043-2 321 869 nt1 827 nt · Forward (+)
StrandForward (+)Strand sign follows the local context database convention.
Local TCS group span2 320 043-2 323 251 ntGCF_000005845::NC_000913.3::G00021
Quick actions
Local neighborhood
Graphical neighborhood resolved from the local TCS context group on the current contig
GCF_000005845::NC_000913.3::G00021Graphic view
Compact keeps a quick overview. Biotite-like switches to a coordinate-aware biological layout with strand and zoom.
Context labelpairedNeighborhood members are ordered by genomic coordinates.
Contig / repliconNC_000913.3All displayed genes belong to this local TCS context.
Neighborhood span2 320 043-2 323 251 nt3 209 nt
Members21 current focus gene
Local TCS group mapArrow direction follows strand. The current gene is highlighted with a stronger outline.
2 320 043 nt2 323 251 nt
Clusters
CD-HIT memberships and selected cluster details for the current gene class
Available memberships1 cluster
PFAM architecturePAS + HisKA + HATPase_c3 domains in the representative PFAM annotation.
PFAM architecture for HKOC_1012972
Simplified PFAM architecture for HKOC_1012972
PFAM domain coverage: 273 / 608 aa (44.9%)
1 aa608 aa
PASHisKAHATPase_c
- Simplified architecture: PAS + HisKA + HATPase_c
- Raw architecture: PAS[265-369] | HisKA[389-451] | HATPase_c[496-600]
- Domain count: 3
- Matched identifier: HKOC_1012972
- Positioned domains: PAS 265-369 ; HisKA 389-451 ; HATPase_c 496-600
Cluster members and taxonomy
Representative gene: GCF_000005845#b2219
Sankey plot built from the taxonomy of all members in the selected cluster.
Genome taxonomy
Unknown
Taxonomy recordUnknownTaxon ID 511 145 · GCF_000005845
AssemblyASM584v2 · Complete Genomereference genome · haploid
Genome composition4 641 652 bp · 51,0% GCEscherichia coli str. K-12 substr. MG1655
Signal transduction countsGenes 63 · HK 31 · RR 32CheA 2 · PP 0
Ranked taxonomy7 ranked levels available
SuperkingdomBacteriaKingdomPseudomonadatiPhylumPseudomonadotaClassGammaproteobacteriaOrderEnterobacteralesFamilyEnterobacteriaceaeGenusEscherichia
Lineage path7 lineage nodes
1Bacteria2Pseudomonadati3Pseudomonadota4Gammaproteobacteria5Enterobacterales6Enterobacteriaceae7Escherichia
Related genes
Preview from the same derived genome key