Gene detail

E1112_RS02420

Histidine kinase, Classic

Clostridioides difficile · GCF_900687725

ClassHKTypeClassicLength900 aaTM0ValidatedNoCompleteYesContextpaired
Gene IDGCF_900687725#E1112_RS02420Stable P2CS identifier used across views.
GenomeGCF_900687725Bacteria; Bacillati; Bacillota; Clostridia; Peptostreptococcales; Peptostreptococcaceae; Clostridioides
Selected clusterHKOC_0405929Run 6 · 14 sequences · id 100% · cov 80%
External referencesWP_074048848.1 · MIST4 E1112_RS02420RefSeq · MIST4

Domain signature

Compact overview inferred from the domain field

KdpDGAF_3HisKAHATPase_c
Protein length900 aaLength used to scale native and Biotite-like views.
Annotated domains44 with usable coordinates.
Domain coverage514 / 900 aa (57.1%)Merged over positioned domains only.
Domain description1 KdpD,1 GAF_3,1 HisKA,1 HATPase_cSummary string stored in the genes table.
Signal peptideUnavailableNo TMPRED prediction file matched this gene.
Transmembrane helicesUnavailableConfigure [protein_features] tmpred_root_dir to enable this annotation.
Complete domain annotations
Native P2CS viewFrontend rendering from the parsed domain string and TMPRED protein features.
1 aa900 aa
KdpD: 22-230 aa (209 aa)1GAF_3: 533-656 aa (124 aa)2HisKA: 676-743 aa (68 aa)3HATPase_c: 787-899 aa (113 aa)4
Domain-by-domain annotation4 items
1 KdpD#1
22-230 aa · 209 aa · 23.2% of protein
Raw tokenKdpD:22:1.58e-133:230:209:210
2 GAF_3#2
533-656 aa · 124 aa · 13.8% of protein
Raw tokenGAF_3:533:0.0000057:656:129:129
3 HisKA#3
676-743 aa · 68 aa · 7.6% of protein
Raw tokenHisKA:676:0.0000000000057:743:68:64
4 HATPase_c#4
787-899 aa · 113 aa · 12.6% of protein
Raw tokenHATPase_c:787:1.98e-30:899:113:109
  • Raw architecture: KdpD:22:1.58e-133:230:209:210#GAF_3:533:0.0000057:656:129:129#HisKA:676:0.0000000000057:743:68:64#HATPase_c:787:1.98e-30:899:113:109
  • Domain description: 1 KdpD,1 GAF_3,1 HisKA,1 HATPase_c
  • TM description: N/A
  • TMPRED source: No TMPRED file loaded
  • TMPRED segments: N/A
  • Complete: Yes

Context mapping

Resolved via p2cs_tcs_context.db when a locus tag match exists

Context labelpairedGCF_900687725::NZ_CAACZY010000001.1::G00006
Group size22 locus tags listed below.
HK / RR1 / 1Counts resolved for the local TCS neighborhood.
Context span503017-506451Genomic interval covered by the local TCS group.
Identifiers
Old locus tagSAMEA1402390_00474RefSeq proteinWP_074048848.1
Context group IDGCF_900687725::NZ_CAACZY010000001.1::G00006
Context members
E1112_RS02415E1112_RS02420
Partner locus tags
E1112_RS02415E1112_RS02420
Partner old locus tags
SAMEA1402390_00473SAMEA1402390_00474
Partner protein IDs

External references

Resolved via p2cs_annexes.db when the RefSeq protein is present in the annex table

No UniProt / GO / PubMed mapping was found for WP_074048848.1.

Genomic coordinates

Resolved via p2cs_tcs_context.db when the current locus tag is present in the local context table

Current locus tagE1112_RS02420Primary locus identifier stored in the genes table.
Old locus tagSAMEA1402390_00474Legacy locus tag recovered from the local context mapping.
Contig / repliconNZ_CAACZY010000001.1Sequence record reported by the local genomic context database.
Genomic interval503 749-506 451 nt2 703 nt · Reverse (-)
StrandReverse (-)Strand sign follows the local context database convention.
Local TCS group span503 017-506 451 ntGCF_900687725::NZ_CAACZY010000001.1::G00006

Local neighborhood

Graphical neighborhood resolved from the local TCS context group on the current contig

GCF_900687725::NZ_CAACZY010000001.1::G00006

Compact keeps a quick overview. Biotite-like switches to a coordinate-aware biological layout with strand and zoom.

Context labelpairedNeighborhood members are ordered by genomic coordinates.
Contig / repliconNZ_CAACZY010000001.1All displayed genes belong to this local TCS context.
Neighborhood span503 017-506 451 nt3 435 nt
Members21 current focus gene
Local TCS group mapArrow direction follows strand. The current gene is highlighted with a stronger outline.
503 017 nt506 451 nt
Neighborhood gene cards

2 genes in the current local neighborhood.

E1112_RS02415GCF_900687725#E1112_RS02415
RROmpR

503 017-503 715 nt · Reverse (-)

Old locus SAMEA1402390_00473RefSeq WP_003439430.1
E1112_RS02420GCF_900687725#E1112_RS02420
HKClassicCurrent focus

503 749-506 451 nt · Reverse (-)

Old locus SAMEA1402390_00474RefSeq WP_074048848.1

Clusters

CD-HIT memberships and selected cluster details for the current gene class

Selected clusterHKOC_0405929Run 6 · HK · 14 sequences
Representative sequenceGCF_002301405#BGU19_RS04905Use this link to inspect the representative gene detail.
PFAM architectureKdpD + DUF4118 + HisKA + HATPase_c4 domains in the representative PFAM annotation.

PFAM architecture for HKOC_0405929

Simplified PFAM architecture for HKOC_0405929

PFAM domain coverage: 494 / 900 aa (54.9%)

1 aa900 aa
KdpD: 22-230 aaKdpDDUF4118: 409-514 aaDUF4118HisKA: 676-743 aaHisKAHATPase_c: 788-898 aaHATPase_c
KdpDDUF4118HisKAHATPase_c
  • Simplified architecture: KdpD + DUF4118 + HisKA + HATPase_c
  • Raw architecture: KdpD[22-230] | DUF4118[409-514] | HisKA[676-743] | HATPase_c[788-898]
  • Domain count: 4
  • Matched identifier: HKOC_0405929
  • Positioned domains: KdpD 22-230 ; DUF4118 409-514 ; HisKA 676-743 ; HATPase_c 788-898
Cluster members and taxonomy
Visualization

Representative gene: GCF_002301405#BGU19_RS04905

Sankey plot built from the taxonomy of all members in the selected cluster.

Genome taxonomy

Unknown

Taxonomy recordUnknownTaxon ID 1 496 · GCF_900687725
Assembly7614_4#70 · Contighaploid
Genome composition4 218 281 bp · 28,5% GCClostridioides difficile
Signal transduction countsGenes 102 · HK 49 · RR 52CheA 1 · PP 1
Ranked taxonomy7 ranked levels available
SuperkingdomBacteriaKingdomBacillatiPhylumBacillotaClassClostridiaOrderPeptostreptococcalesFamilyPeptostreptococcaceaeGenusClostridioides
Lineage path7 lineage nodes
1Bacteria2Bacillati3Bacillota4Clostridia5Peptostreptococcales6Peptostreptococcaceae7Clostridioides

Related genes

Preview from the same derived genome key