Gene detail

ACE3NE_RS03220

Histidine kinase, Classic

Clostridioides difficile · GCF_042867505

ClassHKTypeClassicLength899 aaTM0ValidatedNoCompleteYesContextpaired
Gene IDGCF_042867505#ACE3NE_RS03220Stable P2CS identifier used across views.
GenomeGCF_042867505Bacteria; Bacillati; Bacillota; Clostridia; Peptostreptococcales; Peptostreptococcaceae; Clostridioides
Selected clusterHKOC_0406014Run 6 · 22 sequences · id 100% · cov 80%
External referencesWP_070117580.1 · MIST4 ACE3NE_RS03220RefSeq · MIST4

Domain signature

Compact overview inferred from the domain field

KdpDGAF_3HisKAHATPase_c
Protein length899 aaLength used to scale native and Biotite-like views.
Annotated domains44 with usable coordinates.
Domain coverage514 / 899 aa (57.2%)Merged over positioned domains only.
Domain description1 KdpD,1 GAF_3,1 HisKA,1 HATPase_cSummary string stored in the genes table.
Signal peptideUnavailableNo TMPRED prediction file matched this gene.
Transmembrane helicesUnavailableConfigure [protein_features] tmpred_root_dir to enable this annotation.
Complete domain annotations
Native P2CS viewFrontend rendering from the parsed domain string and TMPRED protein features.
1 aa899 aa
KdpD: 22-230 aa (209 aa)1GAF_3: 533-656 aa (124 aa)2HisKA: 676-743 aa (68 aa)3HATPase_c: 787-899 aa (113 aa)4
Domain-by-domain annotation4 items
1 KdpD#1
22-230 aa · 209 aa · 23.2% of protein
Raw tokenKdpD:22:4.84e-134:230:209:210
2 GAF_3#2
533-656 aa · 124 aa · 13.8% of protein
Raw tokenGAF_3:533:0.00000108:656:129:129
3 HisKA#3
676-743 aa · 68 aa · 7.6% of protein
Raw tokenHisKA:676:0.00000000000362:743:68:64
4 HATPase_c#4
787-899 aa · 113 aa · 12.6% of protein
Raw tokenHATPase_c:787:1.73e-30:899:113:109
  • Raw architecture: KdpD:22:4.84e-134:230:209:210#GAF_3:533:0.00000108:656:129:129#HisKA:676:0.00000000000362:743:68:64#HATPase_c:787:1.73e-30:899:113:109
  • Domain description: 1 KdpD,1 GAF_3,1 HisKA,1 HATPase_c
  • TM description: N/A
  • TMPRED source: No TMPRED file loaded
  • TMPRED segments: N/A
  • Complete: Yes

Context mapping

Resolved via p2cs_tcs_context.db when a locus tag match exists

Context labelpairedGCF_042867505::NZ_JBHHOE010000001.1::G00009
Group size22 locus tags listed below.
HK / RR1 / 1Counts resolved for the local TCS neighborhood.
Context span707440-710874Genomic interval covered by the local TCS group.
Identifiers
Old locus tagACE3NE_03220RefSeq proteinWP_070117580.1
Context group IDGCF_042867505::NZ_JBHHOE010000001.1::G00009
Context members
ACE3NE_RS03215ACE3NE_RS03220
Partner locus tags
ACE3NE_RS03215ACE3NE_RS03220
Partner old locus tags
ACE3NE_03215ACE3NE_03220
Partner protein IDs

External references

Resolved via p2cs_annexes.db when the RefSeq protein is present in the annex table

No UniProt / GO / PubMed mapping was found for WP_070117580.1.

Genomic coordinates

Resolved via p2cs_tcs_context.db when the current locus tag is present in the local context table

Current locus tagACE3NE_RS03220Primary locus identifier stored in the genes table.
Old locus tagACE3NE_03220Legacy locus tag recovered from the local context mapping.
Contig / repliconNZ_JBHHOE010000001.1Sequence record reported by the local genomic context database.
Genomic interval708 175-710 874 nt2 700 nt · Reverse (-)
StrandReverse (-)Strand sign follows the local context database convention.
Local TCS group span707 440-710 874 ntGCF_042867505::NZ_JBHHOE010000001.1::G00009

Local neighborhood

Graphical neighborhood resolved from the local TCS context group on the current contig

GCF_042867505::NZ_JBHHOE010000001.1::G00009

Compact keeps a quick overview. Biotite-like switches to a coordinate-aware biological layout with strand and zoom.

Context labelpairedNeighborhood members are ordered by genomic coordinates.
Contig / repliconNZ_JBHHOE010000001.1All displayed genes belong to this local TCS context.
Neighborhood span707 440-710 874 nt3 435 nt
Members21 current focus gene
Local TCS group mapArrow direction follows strand. The current gene is highlighted with a stronger outline.
707 440 nt710 874 nt
Neighborhood gene cards

2 genes in the current local neighborhood.

ACE3NE_RS03215GCF_042867505#ACE3NE_RS03215
RROmpR

707 440-708 138 nt · Reverse (-)

Old locus ACE3NE_03215RefSeq WP_003428622.1
ACE3NE_RS03220GCF_042867505#ACE3NE_RS03220
HKClassicCurrent focus

708 175-710 874 nt · Reverse (-)

Old locus ACE3NE_03220RefSeq WP_070117580.1

Clusters

CD-HIT memberships and selected cluster details for the current gene class

Selected clusterHKOC_0406014Run 6 · HK · 22 sequences
Representative sequenceGCF_003327385#DVA95_RS07605Use this link to inspect the representative gene detail.
PFAM architectureKdpD + DUF4118 + HisKA + HATPase_c4 domains in the representative PFAM annotation.

PFAM architecture for HKOC_0406014

Simplified PFAM architecture for HKOC_0406014

PFAM domain coverage: 494 / 900 aa (54.9%)

1 aa900 aa
KdpD: 22-230 aaKdpDDUF4118: 409-514 aaDUF4118HisKA: 676-743 aaHisKAHATPase_c: 788-898 aaHATPase_c
KdpDDUF4118HisKAHATPase_c
  • Simplified architecture: KdpD + DUF4118 + HisKA + HATPase_c
  • Raw architecture: KdpD[22-230] | DUF4118[409-514] | HisKA[676-743] | HATPase_c[788-898]
  • Domain count: 4
  • Matched identifier: HKOC_0406014
  • Positioned domains: KdpD 22-230 ; DUF4118 409-514 ; HisKA 676-743 ; HATPase_c 788-898
Cluster members and taxonomy
Visualization

Representative gene: GCF_003327385#DVA95_RS07605

Sankey plot built from the taxonomy of all members in the selected cluster.

Genome taxonomy

Unknown

Taxonomy recordUnknownTaxon ID 1 496 · GCF_042867505
AssemblyASM4286750v1 · Contighaploid
Genome composition4 154 568 bp · 28,5% GCClostridioides difficile
Signal transduction countsGenes 100 · HK 48 · RR 52CheA 1 · PP 0
Ranked taxonomy7 ranked levels available
SuperkingdomBacteriaKingdomBacillatiPhylumBacillotaClassClostridiaOrderPeptostreptococcalesFamilyPeptostreptococcaceaeGenusClostridioides
Lineage path7 lineage nodes
1Bacteria2Bacillati3Bacillota4Clostridia5Peptostreptococcales6Peptostreptococcaceae7Clostridioides

Related genes

Preview from the same derived genome key