Gene detail

I6E59_RS11025

Histidine kinase, Classic

Clostridioides difficile · GCF_021532205

ClassHKTypeClassicLength904 aaTM0ValidatedNoCompleteYesContextpaired
Gene IDGCF_021532205#I6E59_RS11025Stable P2CS identifier used across views.
GenomeGCF_021532205Bacteria; Bacillati; Bacillota; Clostridia; Peptostreptococcales; Peptostreptococcaceae; Clostridioides
Selected clusterHKOC_0400722Run 6 · 1 sequences · id 100% · cov 80% · representative
External referencesWP_235423812.1 · MIST4 I6E59_RS11025RefSeq · MIST4

Domain signature

Compact overview inferred from the domain field

KdpDGAF_3HisKAHATPase_c
Protein length904 aaLength used to scale native and Biotite-like views.
Annotated domains44 with usable coordinates.
Domain coverage514 / 904 aa (56.9%)Merged over positioned domains only.
Domain description1 KdpD,1 GAF_3,1 HisKA,1 HATPase_cSummary string stored in the genes table.
Signal peptideUnavailableNo TMPRED prediction file matched this gene.
Transmembrane helicesUnavailableConfigure [protein_features] tmpred_root_dir to enable this annotation.
Complete domain annotations
Native P2CS viewFrontend rendering from the parsed domain string and TMPRED protein features.
1 aa904 aa
KdpD: 22-230 aa (209 aa)1GAF_3: 537-660 aa (124 aa)2HisKA: 680-747 aa (68 aa)3HATPase_c: 791-903 aa (113 aa)4
Domain-by-domain annotation4 items
1 KdpD#1
22-230 aa · 209 aa · 23.1% of protein
Raw tokenKdpD:22:8.17e-134:230:209:210
2 GAF_3#2
537-660 aa · 124 aa · 13.7% of protein
Raw tokenGAF_3:537:0.00000575:660:129:129
3 HisKA#3
680-747 aa · 68 aa · 7.5% of protein
Raw tokenHisKA:680:0.00000000000615:747:68:64
4 HATPase_c#4
791-903 aa · 113 aa · 12.5% of protein
Raw tokenHATPase_c:791:9.97e-30:903:113:109
  • Raw architecture: KdpD:22:8.17e-134:230:209:210#GAF_3:537:0.00000575:660:129:129#HisKA:680:0.00000000000615:747:68:64#HATPase_c:791:9.97e-30:903:113:109
  • Domain description: 1 KdpD,1 GAF_3,1 HisKA,1 HATPase_c
  • TM description: N/A
  • TMPRED source: No TMPRED file loaded
  • TMPRED segments: N/A
  • Complete: Yes

Context mapping

Resolved via p2cs_tcs_context.db when a locus tag match exists

Context labelpairedGCF_021532205::NZ_JADYVA010000012.1::G00002
Group size22 locus tags listed below.
HK / RR1 / 1Counts resolved for the local TCS neighborhood.
Context span11479-14925Genomic interval covered by the local TCS group.
Identifiers
Old locus tagI6E59_10970RefSeq proteinWP_235423812.1
Context group IDGCF_021532205::NZ_JADYVA010000012.1::G00002
Context members
I6E59_RS11025I6E59_RS11030
Partner locus tags
I6E59_RS11025I6E59_RS11030
Partner old locus tags
I6E59_10970I6E59_10975
Partner protein IDs

External references

Resolved via p2cs_annexes.db when the RefSeq protein is present in the annex table

No UniProt / GO / PubMed mapping was found for WP_235423812.1.

Genomic coordinates

Resolved via p2cs_tcs_context.db when the current locus tag is present in the local context table

Current locus tagI6E59_RS11025Primary locus identifier stored in the genes table.
Old locus tagI6E59_10970Legacy locus tag recovered from the local context mapping.
Contig / repliconNZ_JADYVA010000012.1Sequence record reported by the local genomic context database.
Genomic interval11 479-14 193 nt2 715 nt · Forward (+)
StrandForward (+)Strand sign follows the local context database convention.
Local TCS group span11 479-14 925 ntGCF_021532205::NZ_JADYVA010000012.1::G00002

Local neighborhood

Graphical neighborhood resolved from the local TCS context group on the current contig

GCF_021532205::NZ_JADYVA010000012.1::G00002

Compact keeps a quick overview. Biotite-like switches to a coordinate-aware biological layout with strand and zoom.

Context labelpairedNeighborhood members are ordered by genomic coordinates.
Contig / repliconNZ_JADYVA010000012.1All displayed genes belong to this local TCS context.
Neighborhood span11 479-14 925 nt3 447 nt
Members21 current focus gene
Local TCS group mapArrow direction follows strand. The current gene is highlighted with a stronger outline.
11 479 nt14 925 nt
Neighborhood gene cards

2 genes in the current local neighborhood.

I6E59_RS11025GCF_021532205#I6E59_RS11025
HKClassicCurrent focus

11 479-14 193 nt · Forward (+)

Old locus I6E59_10970RefSeq WP_235423812.1
I6E59_RS11030GCF_021532205#I6E59_RS11030
RROmpR

14 227-14 925 nt · Forward (+)

Old locus I6E59_10975RefSeq WP_003439430.1

Clusters

CD-HIT memberships and selected cluster details for the current gene class

Selected clusterHKOC_0400722Run 6 · HK · 1 sequences
Representative sequenceGCF_021532205#I6E59_RS11025The current gene is the representative for this cluster.
PFAM architectureKdpD + DUF4118 + HisKA + HATPase_c4 domains in the representative PFAM annotation.

PFAM architecture for HKOC_0400722

Simplified PFAM architecture for HKOC_0400722

PFAM domain coverage: 494 / 904 aa (54.6%)

1 aa904 aa
KdpD: 22-230 aaKdpDDUF4118: 413-518 aaDUF4118HisKA: 680-747 aaHisKAHATPase_c: 792-902 aaHATPase_c
KdpDDUF4118HisKAHATPase_c
  • Simplified architecture: KdpD + DUF4118 + HisKA + HATPase_c
  • Raw architecture: KdpD[22-230] | DUF4118[413-518] | HisKA[680-747] | HATPase_c[792-902]
  • Domain count: 4
  • Matched identifier: HKOC_0400722
  • Positioned domains: KdpD 22-230 ; DUF4118 413-518 ; HisKA 680-747 ; HATPase_c 792-902
Cluster members and taxonomy
Visualization

Representative gene: GCF_021532205#I6E59_RS11025

Sankey plot built from the taxonomy of all members in the selected cluster.

Genome taxonomy

Unknown

Taxonomy recordUnknownTaxon ID 1 496 · GCF_021532205
AssemblyASM2153220v1 · Contighaploid
Genome composition4 148 448 bp · 28,5% GCClostridioides difficile
Signal transduction countsGenes 99 · HK 48 · RR 51CheA 1 · PP 0
Ranked taxonomy7 ranked levels available
SuperkingdomBacteriaKingdomBacillatiPhylumBacillotaClassClostridiaOrderPeptostreptococcalesFamilyPeptostreptococcaceaeGenusClostridioides
Lineage path7 lineage nodes
1Bacteria2Bacillati3Bacillota4Clostridia5Peptostreptococcales6Peptostreptococcaceae7Clostridioides

Related genes

Preview from the same derived genome key