Gene detail

AWN77_RS18555

Histidine kinase, Classic

Clostridioides difficile · GCF_002940825

ClassHKTypeClassicLength469 aaTM0ValidatedNoCompleteYesContextpaired
Gene IDGCF_002940825#AWN77_RS18555Stable P2CS identifier used across views.
GenomeGCF_002940825Bacteria; Bacillati; Bacillota; Clostridia; Peptostreptococcales; Peptostreptococcaceae; Clostridioides
Selected clusterHKOC_1727043Run 6 · 254 sequences · id 100% · cov 80%
External referencesWP_003428684.1 · A0A9P3YKS6 · MIST4 AWN77_RS18555RefSeq · UniProt · MIST4

Domain signature

Compact overview inferred from the domain field

H_kinase_NHisKA_2HATPase_c
Protein length469 aaLength used to scale native and Biotite-like views.
Annotated domains33 with usable coordinates.
Domain coverage304 / 469 aa (64.8%)Merged over positioned domains only.
Domain description1 H_kinase_N,1 HisKA_2,1 HATPase_cSummary string stored in the genes table.
Signal peptideUnavailableNo TMPRED prediction file matched this gene.
Transmembrane helicesUnavailableConfigure [protein_features] tmpred_root_dir to enable this annotation.
Complete domain annotations
Native P2CS viewFrontend rendering from the parsed domain string and TMPRED protein features.
1 aa469 aa
H_kinase_N: 12-142 aa (131 aa)1HisKA_2: 276-350 aa (75 aa)2HATPase_c: 370-467 aa (98 aa)3
Domain-by-domain annotation3 items
1 H_kinase_N#1
12-142 aa · 131 aa · 27.9% of protein
Raw tokenH_kinase_N:12:4.4e-37:142:132:139
2 HisKA_2#2
276-350 aa · 75 aa · 16.0% of protein
Raw tokenHisKA_2:276:2.55e-16:350:76:76
3 HATPase_c#3
370-467 aa · 98 aa · 20.9% of protein
Raw tokenHATPase_c:370:0.000000206:467:114:109
  • Raw architecture: H_kinase_N:12:4.4e-37:142:132:139#HisKA_2:276:2.55e-16:350:76:76#HATPase_c:370:0.000000206:467:114:109
  • Domain description: 1 H_kinase_N,1 HisKA_2,1 HATPase_c
  • TM description: N/A
  • TMPRED source: No TMPRED file loaded
  • TMPRED segments: N/A
  • Complete: Yes

Context mapping

Resolved via p2cs_tcs_context.db when a locus tag match exists

Context labelpairedGCF_002940825::NZ_LRDM01000197.1::G00056
Group size22 locus tags listed below.
HK / RR1 / 1Counts resolved for the local TCS neighborhood.
Context span84447-86424Genomic interval covered by the local TCS group.
Identifiers
Old locus tagAWN77_05180RefSeq proteinWP_003428684.1
Context group IDGCF_002940825::NZ_LRDM01000197.1::G00056
Context members
AWN77_RS18555AWN77_RS18560
Partner locus tags
AWN77_RS18555AWN77_RS18560
Partner old locus tags
AWN77_05180AWN77_05185
Partner protein IDs

External references

Resolved via p2cs_annexes.db when the RefSeq protein is present in the annex table

RefSeqWP_003428684.1Primary protein accession used for annex mappings.
UniProt accessionA0A9P3YKS6Primary UniProt accession resolved in the annex database.
UniProt IDA0A9P3YKS6_CLODIDisplay identifier provided by UniProt.
GO / PubMed3 / 1Unique GO terms and literature references available below.
PubMed

Genomic coordinates

Resolved via p2cs_tcs_context.db when the current locus tag is present in the local context table

Current locus tagAWN77_RS18555Primary locus identifier stored in the genes table.
Old locus tagAWN77_05180Legacy locus tag recovered from the local context mapping.
Contig / repliconNZ_LRDM01000197.1Sequence record reported by the local genomic context database.
Genomic interval84 447-85 856 nt1 410 nt · Reverse (-)
StrandReverse (-)Strand sign follows the local context database convention.
Local TCS group span84 447-86 424 ntGCF_002940825::NZ_LRDM01000197.1::G00056

Local neighborhood

Graphical neighborhood resolved from the local TCS context group on the current contig

GCF_002940825::NZ_LRDM01000197.1::G00056

Compact keeps a quick overview. Biotite-like switches to a coordinate-aware biological layout with strand and zoom.

Context labelpairedNeighborhood members are ordered by genomic coordinates.
Contig / repliconNZ_LRDM01000197.1All displayed genes belong to this local TCS context.
Neighborhood span84 447-86 424 nt1 978 nt
Members21 current focus gene
Local TCS group mapArrow direction follows strand. The current gene is highlighted with a stronger outline.
84 447 nt86 424 nt
Neighborhood gene cards

2 genes in the current local neighborhood.

AWN77_RS18555GCF_002940825#AWN77_RS18555
HKClassicCurrent focus

84 447-85 856 nt · Reverse (-)

Old locus AWN77_05180RefSeq WP_003428684.1
AWN77_RS18560GCF_002940825#AWN77_RS18560
RRAmiR_NasR

85 849-86 424 nt · Reverse (-)

Old locus AWN77_05185RefSeq WP_003428683.1

Clusters

CD-HIT memberships and selected cluster details for the current gene class

Selected clusterHKOC_1727043Run 6 · HK · 254 sequences
Representative sequenceGCF_000210395#CDM68_RS09835Use this link to inspect the representative gene detail.
PFAM architectureGAF_PdtaS + HisKA_2 + HATPase_c3 domains in the representative PFAM annotation.

PFAM architecture for HKOC_1727043

Simplified PFAM architecture for HKOC_1727043

PFAM domain coverage: 302 / 469 aa (64.4%)

1 aa469 aa
GAF_PdtaS: 6-141 aaGAF_PdtaSHisKA_2: 276-347 aaHisKA_2HATPase_c: 373-466 aaHATPase_c
GAF_PdtaSHisKA_2HATPase_c
  • Simplified architecture: GAF_PdtaS + HisKA_2 + HATPase_c
  • Raw architecture: GAF_PdtaS[6-141] | HisKA_2[276-347] | HATPase_c[373-466]
  • Domain count: 3
  • Matched identifier: HKOC_1727043
  • Positioned domains: GAF_PdtaS 6-141 ; HisKA_2 276-347 ; HATPase_c 373-466
Cluster members and taxonomy
Visualization

Representative gene: GCF_000210395#CDM68_RS09835

Sankey plot built from the taxonomy of all members in the selected cluster.

Genome taxonomy

Unknown

Taxonomy recordUnknownTaxon ID 1 496 · GCF_002940825
AssemblyASM294082v1 · Contighaploid
Genome composition4 390 681 bp · 28,5% GCClostridioides difficile
Signal transduction countsGenes 99 · HK 47 · RR 52CheA 1 · PP 0
Ranked taxonomy7 ranked levels available
SuperkingdomBacteriaKingdomBacillatiPhylumBacillotaClassClostridiaOrderPeptostreptococcalesFamilyPeptostreptococcaceaeGenusClostridioides
Lineage path7 lineage nodes
1Bacteria2Bacillati3Bacillota4Clostridia5Peptostreptococcales6Peptostreptococcaceae7Clostridioides

Related genes

Preview from the same derived genome key