Gene detail

BGU60_RS02650

Histidine kinase, Classic

Clostridioides difficile · GCF_002303425

ClassHKTypeClassicLength469 aaTM0ValidatedNoCompleteYesContextpaired
Gene IDGCF_002303425#BGU60_RS02650Stable P2CS identifier used across views.
GenomeGCF_002303425Bacteria; Bacillati; Bacillota; Clostridia; Peptostreptococcales; Peptostreptococcaceae; Clostridioides
Selected clusterHKOC_1727001Run 6 · 282 sequences · id 100% · cov 80%
External referencesWP_003423979.1 · D5Q482 · MIST4 BGU60_RS02650RefSeq · UniProt · MIST4

Domain signature

Compact overview inferred from the domain field

H_kinase_NHisKA_2HATPase_c
Protein length469 aaLength used to scale native and Biotite-like views.
Annotated domains33 with usable coordinates.
Domain coverage304 / 469 aa (64.8%)Merged over positioned domains only.
Domain description1 H_kinase_N,1 HisKA_2,1 HATPase_cSummary string stored in the genes table.
Signal peptideUnavailableNo TMPRED prediction file matched this gene.
Transmembrane helicesUnavailableConfigure [protein_features] tmpred_root_dir to enable this annotation.
Complete domain annotations
Native P2CS viewFrontend rendering from the parsed domain string and TMPRED protein features.
1 aa469 aa
H_kinase_N: 12-142 aa (131 aa)1HisKA_2: 276-350 aa (75 aa)2HATPase_c: 370-467 aa (98 aa)3
Domain-by-domain annotation3 items
1 H_kinase_N#1
12-142 aa · 131 aa · 27.9% of protein
Raw tokenH_kinase_N:12:7.33e-36:142:132:139
2 HisKA_2#2
276-350 aa · 75 aa · 16.0% of protein
Raw tokenHisKA_2:276:3.39e-17:350:76:76
3 HATPase_c#3
370-467 aa · 98 aa · 20.9% of protein
Raw tokenHATPase_c:370:0.000000589:467:114:109
  • Raw architecture: H_kinase_N:12:7.33e-36:142:132:139#HisKA_2:276:3.39e-17:350:76:76#HATPase_c:370:0.000000589:467:114:109
  • Domain description: 1 H_kinase_N,1 HisKA_2,1 HATPase_c
  • TM description: N/A
  • TMPRED source: No TMPRED file loaded
  • TMPRED segments: N/A
  • Complete: Yes

Context mapping

Resolved via p2cs_tcs_context.db when a locus tag match exists

Context labelpairedGCF_002303425::NZ_MOTC01000004.1::G00008
Group size22 locus tags listed below.
HK / RR1 / 1Counts resolved for the local TCS neighborhood.
Context span23134-25111Genomic interval covered by the local TCS group.
Identifiers
Old locus tagBGU60_02570RefSeq proteinWP_003423979.1
Context group IDGCF_002303425::NZ_MOTC01000004.1::G00008
Context members
BGU60_RS02650BGU60_RS02655
Partner locus tags
BGU60_RS02650BGU60_RS02655
Partner old locus tags
BGU60_02570BGU60_02575
Partner protein IDs

External references

Resolved via p2cs_annexes.db when the RefSeq protein is present in the annex table

RefSeqWP_003423979.1Primary protein accession used for annex mappings.
UniProt accessionD5Q482Primary UniProt accession resolved in the annex database.
UniProt IDD5Q482_CLODIDisplay identifier provided by UniProt.
GO / PubMed2 / 0Unique GO terms and literature references available below.

Genomic coordinates

Resolved via p2cs_tcs_context.db when the current locus tag is present in the local context table

Current locus tagBGU60_RS02650Primary locus identifier stored in the genes table.
Old locus tagBGU60_02570Legacy locus tag recovered from the local context mapping.
Contig / repliconNZ_MOTC01000004.1Sequence record reported by the local genomic context database.
Genomic interval23 134-24 543 nt1 410 nt · Reverse (-)
StrandReverse (-)Strand sign follows the local context database convention.
Local TCS group span23 134-25 111 ntGCF_002303425::NZ_MOTC01000004.1::G00008

Local neighborhood

Graphical neighborhood resolved from the local TCS context group on the current contig

GCF_002303425::NZ_MOTC01000004.1::G00008

Compact keeps a quick overview. Biotite-like switches to a coordinate-aware biological layout with strand and zoom.

Context labelpairedNeighborhood members are ordered by genomic coordinates.
Contig / repliconNZ_MOTC01000004.1All displayed genes belong to this local TCS context.
Neighborhood span23 134-25 111 nt1 978 nt
Members21 current focus gene
Local TCS group mapArrow direction follows strand. The current gene is highlighted with a stronger outline.
23 134 nt25 111 nt
Neighborhood gene cards

2 genes in the current local neighborhood.

BGU60_RS02650GCF_002303425#BGU60_RS02650
HKClassicCurrent focus

23 134-24 543 nt · Reverse (-)

Old locus BGU60_02570RefSeq WP_003423979.1
BGU60_RS02655GCF_002303425#BGU60_RS02655
RRAmiR_NasR

24 536-25 111 nt · Reverse (-)

Old locus BGU60_02575RefSeq WP_003423977.1

Clusters

CD-HIT memberships and selected cluster details for the current gene class

Selected clusterHKOC_1727001Run 6 · HK · 282 sequences
Representative sequenceGCF_000164175#HMPREF0220_RS14035Use this link to inspect the representative gene detail.
PFAM architectureGAF_PdtaS + HisKA_2 + HATPase_c3 domains in the representative PFAM annotation.

PFAM architecture for HKOC_1727001

Simplified PFAM architecture for HKOC_1727001

PFAM domain coverage: 305 / 469 aa (65.0%)

1 aa469 aa
GAF_PdtaS: 6-141 aaGAF_PdtaSHisKA_2: 276-350 aaHisKA_2HATPase_c: 373-466 aaHATPase_c
GAF_PdtaSHisKA_2HATPase_c
  • Simplified architecture: GAF_PdtaS + HisKA_2 + HATPase_c
  • Raw architecture: GAF_PdtaS[6-141] | HisKA_2[276-350] | HATPase_c[373-466]
  • Domain count: 3
  • Matched identifier: HKOC_1727001
  • Positioned domains: GAF_PdtaS 6-141 ; HisKA_2 276-350 ; HATPase_c 373-466
Cluster members and taxonomy
Visualization

Representative gene: GCF_000164175#HMPREF0220_RS14035

Sankey plot built from the taxonomy of all members in the selected cluster.

Genome taxonomy

Unknown

Taxonomy recordUnknownTaxon ID 1 496 · GCF_002303425
AssemblyASM230342v1 · Contighaploid
Genome composition4 026 332 bp · 28,5% GCClostridioides difficile
Signal transduction countsGenes 104 · HK 50 · RR 54CheA 1 · PP 0
Ranked taxonomy7 ranked levels available
SuperkingdomBacteriaKingdomBacillatiPhylumBacillotaClassClostridiaOrderPeptostreptococcalesFamilyPeptostreptococcaceaeGenusClostridioides
Lineage path7 lineage nodes
1Bacteria2Bacillati3Bacillota4Clostridia5Peptostreptococcales6Peptostreptococcaceae7Clostridioides

Related genes

Preview from the same derived genome key