1 His_kinase#1
205-283 aa · 79 aa · 19.8% of protein
Raw token
His_kinase:205:2.31e-31:283:80:80P2CS-Web
Two-component systems, rebuilt for exploration
Gene detail
C674_RS12845
Histidine kinase, Classic
Clostridioides difficile F480 · GCF_000452285
ClassHKTypeClassicLength400 aaTM0ValidatedNoCompleteYesContextpaired
Gene IDGCF_000452285#C674_RS12845Stable P2CS identifier used across views.
GenomeGCF_000452285Bacteria; Bacillati; Bacillota; Clostridia; Peptostreptococcales; Peptostreptococcaceae; Clostridioides
Domain signature
Compact overview inferred from the domain field
His_kinaseHATPase_c
Protein length400 aaLength used to scale native and Biotite-like views.
Annotated domains22 with usable coordinates.
Domain coverage180 / 400 aa (45.0%)Merged over positioned domains only.
Domain description1 His_kinase,1 HATPase_cSummary string stored in the genes table.
Signal peptideUnavailableNo TMPRED prediction file matched this gene.
Transmembrane helicesUnavailableConfigure [protein_features] tmpred_root_dir to enable this annotation.
Complete domain annotations
Native P2CS viewFrontend rendering from the parsed domain string and TMPRED protein features.
1 aa400 aa
Domain-by-domain annotation2 items
2 HATPase_c#2
300-400 aa · 101 aa · 25.3% of protein
Raw token
HATPase_c:300:0.00000000147:400:108:109- Raw architecture: His_kinase:205:2.31e-31:283:80:80#HATPase_c:300:0.00000000147:400:108:109
- Domain description: 1 His_kinase,1 HATPase_c
- TM description: N/A
- TMPRED source: No TMPRED file loaded
- TMPRED segments: N/A
- Complete: Yes
Context mapping
Resolved via p2cs_tcs_context.db when a locus tag match exists
Context labelpairedGCF_000452285::NZ_AVNE01000024.1::G00043
Group size22 locus tags listed below.
HK / RR1 / 1Counts resolved for the local TCS neighborhood.
Context span100160-102137Genomic interval covered by the local TCS group.
Identifiers
Old locus tagC674_2598RefSeq proteinWP_021367036.1
Context group ID
GCF_000452285::NZ_AVNE01000024.1::G00043Context members
C674_RS12840C674_RS12845
Partner locus tags
C674_RS12840C674_RS12845
Partner old locus tags
C674_2597C674_2598
Partner protein IDs
External references
Resolved via p2cs_annexes.db when the RefSeq protein is present in the annex table
RefSeqWP_021367036.1Primary protein accession used for annex mappings.
UniProt accessionA0A069A9I9Primary UniProt accession resolved in the annex database.
UniProt IDA0A069A9I9_CLODIDisplay identifier provided by UniProt.
GO / PubMed4 / 0Unique GO terms and literature references available below.
Reference hubs
Genomic coordinates
Resolved via p2cs_tcs_context.db when the current locus tag is present in the local context table
Current locus tagC674_RS12845Primary locus identifier stored in the genes table.
Old locus tagC674_2598Legacy locus tag recovered from the local context mapping.
Contig / repliconNZ_AVNE01000024.1Sequence record reported by the local genomic context database.
Genomic interval100 935-102 137 nt1 203 nt · Reverse (-)
StrandReverse (-)Strand sign follows the local context database convention.
Local TCS group span100 160-102 137 ntGCF_000452285::NZ_AVNE01000024.1::G00043
Quick actions
Local neighborhood
Graphical neighborhood resolved from the local TCS context group on the current contig
GCF_000452285::NZ_AVNE01000024.1::G00043Graphic view
Compact keeps a quick overview. Biotite-like switches to a coordinate-aware biological layout with strand and zoom.
Context labelpairedNeighborhood members are ordered by genomic coordinates.
Contig / repliconNZ_AVNE01000024.1All displayed genes belong to this local TCS context.
Neighborhood span100 160-102 137 nt1 978 nt
Members21 current focus gene
Local TCS group mapArrow direction follows strand. The current gene is highlighted with a stronger outline.
100 160 nt102 137 nt
Neighborhood gene cards
2 genes in the current local neighborhood.
C674_RS12840GCF_000452285#C674_RS12840
RRLytTR
100 160-100 930 nt · Reverse (-)
C674_RS12845GCF_000452285#C674_RS12845
HKClassicCurrent focus
100 935-102 137 nt · Reverse (-)
Clusters
CD-HIT memberships and selected cluster details for the current gene class
Available memberships1 cluster
Representative sequenceGCF_000448765#QC5_RS13140Use this link to inspect the representative gene detail.
PFAM architecture5TM-5TMR_LYT + His_kinase + HATPase_c3 domains in the representative PFAM annotation.
PFAM architecture for HKOC_2440982
Simplified PFAM architecture for HKOC_2440982
PFAM domain coverage: 342 / 400 aa (85.5%)
1 aa400 aa
5TM-5TMR_LYTHis_kinaseHATPase_c
- Simplified architecture: 5TM-5TMR_LYT + His_kinase + HATPase_c
- Raw architecture: 5TM-5TMR_LYT[27-190] | His_kinase[205-281] | HATPase_c[299-399]
- Domain count: 3
- Matched identifier: HKOC_2440982
- Positioned domains: 5TM-5TMR_LYT 27-190 ; His_kinase 205-281 ; HATPase_c 299-399
Cluster members and taxonomy
Representative gene: GCF_000448765#QC5_RS13140
Sankey plot built from the taxonomy of all members in the selected cluster.
Genome taxonomy
Unknown
Taxonomy recordUnknownTaxon ID 1 232 193 · GCF_000452285
AssemblyASM45228v2 · Contighaploid
Genome composition3 989 604 bp · 28,5% GCClostridioides difficile F480
Signal transduction countsGenes 98 · HK 47 · RR 51CheA 1 · PP 0
Ranked taxonomy7 ranked levels available
SuperkingdomBacteriaKingdomBacillatiPhylumBacillotaClassClostridiaOrderPeptostreptococcalesFamilyPeptostreptococcaceaeGenusClostridioides
Lineage path7 lineage nodes
1Bacteria2Bacillati3Bacillota4Clostridia5Peptostreptococcales6Peptostreptococcaceae7Clostridioides
Related genes
Preview from the same derived genome key