Gene detail

QC5_RS09425

Histidine kinase, Classic

Clostridioides difficile CD34 · GCF_000448765

ClassHKTypeClassicLength900 aaTM0ValidatedNoCompleteYesContextpaired
Gene IDGCF_000448765#QC5_RS09425Stable P2CS identifier used across views.
GenomeGCF_000448765Bacteria; Bacillati; Bacillota; Clostridia; Peptostreptococcales; Peptostreptococcaceae; Clostridioides
Selected clusterHKOC_0405720Run 6 · 95 sequences · id 100% · cov 80% · representative
External referencesWP_021366764.1 · A0A069AHS9 · MIST4 QC5_RS09425RefSeq · UniProt · MIST4

Domain signature

Compact overview inferred from the domain field

KdpDGAF_3HisKAHATPase_c
Protein length900 aaLength used to scale native and Biotite-like views.
Annotated domains44 with usable coordinates.
Domain coverage514 / 900 aa (57.1%)Merged over positioned domains only.
Domain description1 KdpD,1 GAF_3,1 HisKA,1 HATPase_cSummary string stored in the genes table.
Signal peptideUnavailableNo TMPRED prediction file matched this gene.
Transmembrane helicesUnavailableConfigure [protein_features] tmpred_root_dir to enable this annotation.
Complete domain annotations
Native P2CS viewFrontend rendering from the parsed domain string and TMPRED protein features.
1 aa900 aa
KdpD: 22-230 aa (209 aa)1GAF_3: 533-656 aa (124 aa)2HisKA: 676-743 aa (68 aa)3HATPase_c: 787-899 aa (113 aa)4
Domain-by-domain annotation4 items
1 KdpD#1
22-230 aa · 209 aa · 23.2% of protein
Raw tokenKdpD:22:1.56e-133:230:209:210
2 GAF_3#2
533-656 aa · 124 aa · 13.8% of protein
Raw tokenGAF_3:533:0.00000572:656:129:129
3 HisKA#3
676-743 aa · 68 aa · 7.6% of protein
Raw tokenHisKA:676:0.00000000000586:743:68:64
4 HATPase_c#4
787-899 aa · 113 aa · 12.6% of protein
Raw tokenHATPase_c:787:1.97e-30:899:113:109
  • Raw architecture: KdpD:22:1.56e-133:230:209:210#GAF_3:533:0.00000572:656:129:129#HisKA:676:0.00000000000586:743:68:64#HATPase_c:787:1.97e-30:899:113:109
  • Domain description: 1 KdpD,1 GAF_3,1 HisKA,1 HATPase_c
  • TM description: N/A
  • TMPRED source: No TMPRED file loaded
  • TMPRED segments: N/A
  • Complete: Yes

Context mapping

Resolved via p2cs_tcs_context.db when a locus tag match exists

Context labelpairedGCF_000448765::NZ_AVGQ01000034.1::G00031
Group size22 locus tags listed below.
HK / RR1 / 1Counts resolved for the local TCS neighborhood.
Context span11638-15072Genomic interval covered by the local TCS group.
Identifiers
Old locus tagQC5_1898RefSeq proteinWP_021366764.1
Context group IDGCF_000448765::NZ_AVGQ01000034.1::G00031
Context members
QC5_RS09425QC5_RS09430
Partner locus tags
QC5_RS09425QC5_RS09430
Partner old locus tags
QC5_1898QC5_1899
Partner protein IDs

External references

Resolved via p2cs_annexes.db when the RefSeq protein is present in the annex table

RefSeqWP_021366764.1Primary protein accession used for annex mappings.
UniProt accessionA0A069AHS9Primary UniProt accession resolved in the annex database.
UniProt IDA0A069AHS9_CLODIDisplay identifier provided by UniProt.
GO / PubMed5 / 0Unique GO terms and literature references available below.

Genomic coordinates

Resolved via p2cs_tcs_context.db when the current locus tag is present in the local context table

Current locus tagQC5_RS09425Primary locus identifier stored in the genes table.
Old locus tagQC5_1898Legacy locus tag recovered from the local context mapping.
Contig / repliconNZ_AVGQ01000034.1Sequence record reported by the local genomic context database.
Genomic interval11 638-14 340 nt2 703 nt · Forward (+)
StrandForward (+)Strand sign follows the local context database convention.
Local TCS group span11 638-15 072 ntGCF_000448765::NZ_AVGQ01000034.1::G00031

Local neighborhood

Graphical neighborhood resolved from the local TCS context group on the current contig

GCF_000448765::NZ_AVGQ01000034.1::G00031

Compact keeps a quick overview. Biotite-like switches to a coordinate-aware biological layout with strand and zoom.

Context labelpairedNeighborhood members are ordered by genomic coordinates.
Contig / repliconNZ_AVGQ01000034.1All displayed genes belong to this local TCS context.
Neighborhood span11 638-15 072 nt3 435 nt
Members21 current focus gene
Local TCS group mapArrow direction follows strand. The current gene is highlighted with a stronger outline.
11 638 nt15 072 nt
Neighborhood gene cards

2 genes in the current local neighborhood.

QC5_RS09425GCF_000448765#QC5_RS09425
HKClassicCurrent focus

11 638-14 340 nt · Forward (+)

Old locus QC5_1898RefSeq WP_021366764.1
QC5_RS09430GCF_000448765#QC5_RS09430
RROmpR

14 374-15 072 nt · Forward (+)

Old locus QC5_1899RefSeq WP_003439430.1

Clusters

CD-HIT memberships and selected cluster details for the current gene class

Selected clusterHKOC_0405720Run 6 · HK · 95 sequences
Representative sequenceGCF_000448765#QC5_RS09425The current gene is the representative for this cluster.
PFAM architectureKdpD + DUF4118 + HisKA + HATPase_c4 domains in the representative PFAM annotation.

PFAM architecture for HKOC_0405720

Simplified PFAM architecture for HKOC_0405720

PFAM domain coverage: 494 / 900 aa (54.9%)

1 aa900 aa
KdpD: 22-230 aaKdpDDUF4118: 409-514 aaDUF4118HisKA: 676-743 aaHisKAHATPase_c: 788-898 aaHATPase_c
KdpDDUF4118HisKAHATPase_c
  • Simplified architecture: KdpD + DUF4118 + HisKA + HATPase_c
  • Raw architecture: KdpD[22-230] | DUF4118[409-514] | HisKA[676-743] | HATPase_c[788-898]
  • Domain count: 4
  • Matched identifier: HKOC_0405720
  • Positioned domains: KdpD 22-230 ; DUF4118 409-514 ; HisKA 676-743 ; HATPase_c 788-898
Cluster members and taxonomy
Visualization

Representative gene: GCF_000448765#QC5_RS09425

Sankey plot built from the taxonomy of all members in the selected cluster.

Genome taxonomy

Unknown

Taxonomy recordUnknownTaxon ID 1 151 260 · GCF_000448765
AssemblyASM44876v2 · Contighaploid
Genome composition4 017 712 bp · 28,0% GCClostridioides difficile CD34
Signal transduction countsGenes 98 · HK 47 · RR 51CheA 1 · PP 0
Ranked taxonomy7 ranked levels available
SuperkingdomBacteriaKingdomBacillatiPhylumBacillotaClassClostridiaOrderPeptostreptococcalesFamilyPeptostreptococcaceaeGenusClostridioides
Lineage path7 lineage nodes
1Bacteria2Bacillati3Bacillota4Clostridia5Peptostreptococcales6Peptostreptococcaceae7Clostridioides

Related genes

Preview from the same derived genome key