Gene detail

EC5761_RS04680

Histidine kinase, Classic

Escherichia coli 576-1 · GCF_000264135

ClassHKTypeClassicLength894 aaTM0ValidatedNoCompleteYesContextpaired
Gene IDGCF_000264135#EC5761_RS04680Stable P2CS identifier used across views.
GenomeGCF_000264135Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Selected clusterHKOC_0418679Run 6 · 1481 sequences · id 100% · cov 80%
External referencesWP_001309343.1 · B7N9T8 · MIST4 EC5761_RS04680RefSeq · UniProt · MIST4

Domain signature

Compact overview inferred from the domain field

KdpDGAF_3HisKAHATPase_c
Protein length894 aaLength used to scale native and Biotite-like views.
Annotated domains44 with usable coordinates.
Domain coverage502 / 894 aa (56.2%)Merged over positioned domains only.
Domain description1 KdpD,1 GAF_3,1 HisKA,1 HATPase_cSummary string stored in the genes table.
Signal peptideUnavailableNo TMPRED prediction file matched this gene.
Transmembrane helicesUnavailableConfigure [protein_features] tmpred_root_dir to enable this annotation.
Complete domain annotations
Native P2CS viewFrontend rendering from the parsed domain string and TMPRED protein features.
1 aa894 aa
KdpD: 21-230 aa (210 aa)1GAF_3: 527-644 aa (118 aa)2HisKA: 664-730 aa (67 aa)3HATPase_c: 774-880 aa (107 aa)4
Domain-by-domain annotation4 items
1 KdpD#1
21-230 aa · 210 aa · 23.5% of protein
Raw tokenKdpD:21:1.44e-142:230:210:210
2 GAF_3#2
527-644 aa · 118 aa · 13.2% of protein
Raw tokenGAF_3:527:0.00000000000437:644:130:129
3 HisKA#3
664-730 aa · 67 aa · 7.5% of protein
Raw tokenHisKA:664:0.0000000000003:730:68:64
4 HATPase_c#4
774-880 aa · 107 aa · 12.0% of protein
Raw tokenHATPase_c:774:9.31e-31:880:107:109
  • Raw architecture: KdpD:21:1.44e-142:230:210:210#GAF_3:527:0.00000000000437:644:130:129#HisKA:664:0.0000000000003:730:68:64#HATPase_c:774:9.31e-31:880:107:109
  • Domain description: 1 KdpD,1 GAF_3,1 HisKA,1 HATPase_c
  • TM description: N/A
  • TMPRED source: No TMPRED file loaded
  • TMPRED segments: N/A
  • Complete: Yes

Context mapping

Resolved via p2cs_tcs_context.db when a locus tag match exists

Context labelpairedGCF_000264135::NZ_AJWS01000361.1::G00033
Group size22 locus tags listed below.
HK / RR1 / 1Counts resolved for the local TCS neighborhood.
Context span19347-22705Genomic interval covered by the local TCS group.
Identifiers
Old locus tagEC5761_21606RefSeq proteinWP_001309343.1
Context group IDGCF_000264135::NZ_AJWS01000361.1::G00033
Context members
EC5761_RS04680EC5761_RS04675
Partner locus tags
EC5761_RS04680EC5761_RS04675
Partner old locus tags
EC5761_21606EC5761_21611
Partner protein IDs

External references

Resolved via p2cs_annexes.db when the RefSeq protein is present in the annex table

RefSeqWP_001309343.1Primary protein accession used for annex mappings.
UniProt accessionB7N9T8Primary UniProt accession resolved in the annex database.
UniProt IDB7N9T8_ECOLUDisplay identifier provided by UniProt.
GO / PubMed5 / 1Unique GO terms and literature references available below.
PubMed

Genomic coordinates

Resolved via p2cs_tcs_context.db when the current locus tag is present in the local context table

Current locus tagEC5761_RS04680Primary locus identifier stored in the genes table.
Old locus tagEC5761_21606Legacy locus tag recovered from the local context mapping.
Contig / repliconNZ_AJWS01000361.1Sequence record reported by the local genomic context database.
Genomic interval19 347-22 031 nt2 685 nt · Forward (+)
StrandForward (+)Strand sign follows the local context database convention.
Local TCS group span19 347-22 705 ntGCF_000264135::NZ_AJWS01000361.1::G00033

Local neighborhood

Graphical neighborhood resolved from the local TCS context group on the current contig

GCF_000264135::NZ_AJWS01000361.1::G00033

Compact keeps a quick overview. Biotite-like switches to a coordinate-aware biological layout with strand and zoom.

Context labelpairedNeighborhood members are ordered by genomic coordinates.
Contig / repliconNZ_AJWS01000361.1All displayed genes belong to this local TCS context.
Neighborhood span19 347-22 705 nt3 359 nt
Members21 current focus gene
Local TCS group mapArrow direction follows strand. The current gene is highlighted with a stronger outline.
19 347 nt22 705 nt
Neighborhood gene cards

2 genes in the current local neighborhood.

EC5761_RS04680GCF_000264135#EC5761_RS04680
HKClassicCurrent focus

19 347-22 031 nt · Forward (+)

Old locus EC5761_21606RefSeq WP_001309343.1
EC5761_RS04675GCF_000264135#EC5761_RS04675
RROmpR

22 028-22 705 nt · Forward (+)

Old locus EC5761_21611RefSeq WP_000186111.1

Clusters

CD-HIT memberships and selected cluster details for the current gene class

Selected clusterHKOC_0418679Run 6 · HK · 1481 sequences
Representative sequenceGCF_036697655#V5292_RS11455Use this link to inspect the representative gene detail.
PFAM architectureKdpD + DUF4118 + GAF_3 + HisKA + HATPase_c5 domains in the representative PFAM annotation.

PFAM architecture for HKOC_0418679

Simplified PFAM architecture for HKOC_0418679

PFAM domain coverage: 608 / 895 aa (67.9%)

1 aa895 aa
KdpD: 22-230 aaKdpDDUF4118: 403-509 aaDUF4118GAF_3: 528-645 aaGAF_3HisKA: 665-731 aaHisKAHATPase_c: 777-883 aaHATPase_c
KdpDDUF4118GAF_3HisKAHATPase_c
  • Simplified architecture: KdpD + DUF4118 + GAF_3 + HisKA + HATPase_c
  • Raw architecture: KdpD[22-230] | DUF4118[403-509] | GAF_3[528-645] | HisKA[665-731] | HATPase_c[777-883]
  • Domain count: 5
  • Matched identifier: HKOC_0418679
  • Positioned domains: KdpD 22-230 ; DUF4118 403-509 ; GAF_3 528-645 ; HisKA 665-731 ; HATPase_c 777-883
Cluster members and taxonomy
Visualization

Representative gene: GCF_036697655#V5292_RS11455

Sankey plot built from the taxonomy of all members in the selected cluster.

Genome taxonomy

Unknown

Taxonomy recordUnknownTaxon ID 752 787 · GCF_000264135
AssemblyASM26413v1 · Contighaploid
Genome composition5 191 076 bp · 50,5% GCEscherichia coli 576-1
Signal transduction countsGenes 61 · HK 29 · RR 32CheA 1 · PP 0
Ranked taxonomy7 ranked levels available
SuperkingdomBacteriaKingdomPseudomonadatiPhylumPseudomonadotaClassGammaproteobacteriaOrderEnterobacteralesFamilyEnterobacteriaceaeGenusEscherichia
Lineage path7 lineage nodes
1Bacteria2Pseudomonadati3Pseudomonadota4Gammaproteobacteria5Enterobacterales6Enterobacteriaceae7Escherichia

Related genes

Preview from the same derived genome key