Gene detail

CDR20291_RS09400

Histidine kinase, Classic

Clostridioides difficile R20291 · GCF_000027105

ClassHKTypeClassicLength900 aaTM0ValidatedNoCompleteYesContextpaired
Gene IDGCF_000027105#CDR20291_RS09400Stable P2CS identifier used across views.
GenomeGCF_000027105Bacteria; Bacillati; Bacillota; Clostridia; Peptostreptococcales; Peptostreptococcaceae; Clostridioides
Selected clusterHKOC_0405625Run 6 · 328 sequences · id 100% · cov 80%
External referencesWP_009893308.1 · A0A0H3N3P1 · MIST4 CDR20291_RS09400RefSeq · UniProt · MIST4

Domain signature

Compact overview inferred from the domain field

KdpDGAF_3HisKAHATPase_c
Protein length900 aaLength used to scale native and Biotite-like views.
Annotated domains44 with usable coordinates.
Domain coverage514 / 900 aa (57.1%)Merged over positioned domains only.
Domain description1 KdpD,1 GAF_3,1 HisKA,1 HATPase_cSummary string stored in the genes table.
Signal peptideUnavailableNo TMPRED prediction file matched this gene.
Transmembrane helicesUnavailableConfigure [protein_features] tmpred_root_dir to enable this annotation.
Complete domain annotations
Native P2CS viewFrontend rendering from the parsed domain string and TMPRED protein features.
1 aa900 aa
KdpD: 22-230 aa (209 aa)1GAF_3: 533-656 aa (124 aa)2HisKA: 676-743 aa (68 aa)3HATPase_c: 787-899 aa (113 aa)4
Domain-by-domain annotation4 items
1 KdpD#1
22-230 aa · 209 aa · 23.2% of protein
Raw tokenKdpD:22:1.07e-133:230:209:210
2 GAF_3#2
533-656 aa · 124 aa · 13.8% of protein
Raw tokenGAF_3:533:0.00000535:656:129:129
3 HisKA#3
676-743 aa · 68 aa · 7.6% of protein
Raw tokenHisKA:676:0.00000000000584:743:68:64
4 HATPase_c#4
787-899 aa · 113 aa · 12.6% of protein
Raw tokenHATPase_c:787:1.97e-30:899:113:109
  • Raw architecture: KdpD:22:1.07e-133:230:209:210#GAF_3:533:0.00000535:656:129:129#HisKA:676:0.00000000000584:743:68:64#HATPase_c:787:1.97e-30:899:113:109
  • Domain description: 1 KdpD,1 GAF_3,1 HisKA,1 HATPase_c
  • TM description: N/A
  • TMPRED source: No TMPRED file loaded
  • TMPRED segments: N/A
  • Complete: Yes

Context mapping

Resolved via p2cs_tcs_context.db when a locus tag match exists

Context labelpairedGCF_000027105::NC_013316.1::G00031
Group size22 locus tags listed below.
HK / RR1 / 1Counts resolved for the local TCS neighborhood.
Context span2019004-2022438Genomic interval covered by the local TCS group.
Identifiers
Old locus tagCDR20291_1723RefSeq proteinWP_009893308.1
Context group IDGCF_000027105::NC_013316.1::G00031
Context members
CDR20291_RS09400CDR20291_RS09405
Partner locus tags
CDR20291_RS09400CDR20291_RS09405
Partner old locus tags
CDR20291_1723CDR20291_1724
Partner protein IDs

External references

Resolved via p2cs_annexes.db when the RefSeq protein is present in the annex table

RefSeqWP_009893308.1Primary protein accession used for annex mappings.
UniProt accessionA0A0H3N3P1Primary UniProt accession resolved in the annex database.
UniProt IDA0A0H3N3P1_CLODCDisplay identifier provided by UniProt.
GO / PubMed5 / 1Unique GO terms and literature references available below.
PubMed

Genomic coordinates

Resolved via p2cs_tcs_context.db when the current locus tag is present in the local context table

Current locus tagCDR20291_RS09400Primary locus identifier stored in the genes table.
Old locus tagCDR20291_1723Legacy locus tag recovered from the local context mapping.
Contig / repliconNC_013316.1Sequence record reported by the local genomic context database.
Genomic interval2 019 004-2 021 706 nt2 703 nt · Forward (+)
StrandForward (+)Strand sign follows the local context database convention.
Local TCS group span2 019 004-2 022 438 ntGCF_000027105::NC_013316.1::G00031

Local neighborhood

Graphical neighborhood resolved from the local TCS context group on the current contig

GCF_000027105::NC_013316.1::G00031

Compact keeps a quick overview. Biotite-like switches to a coordinate-aware biological layout with strand and zoom.

Context labelpairedNeighborhood members are ordered by genomic coordinates.
Contig / repliconNC_013316.1All displayed genes belong to this local TCS context.
Neighborhood span2 019 004-2 022 438 nt3 435 nt
Members21 current focus gene
Local TCS group mapArrow direction follows strand. The current gene is highlighted with a stronger outline.
2 019 004 nt2 022 438 nt
Neighborhood gene cards

2 genes in the current local neighborhood.

CDR20291_RS09400GCF_000027105#CDR20291_RS09400
HKClassicCurrent focus

2 019 004-2 021 706 nt · Forward (+)

Old locus CDR20291_1723RefSeq WP_009893308.1
CDR20291_RS09405GCF_000027105#CDR20291_RS09405
RROmpR

2 021 740-2 022 438 nt · Forward (+)

Old locus CDR20291_1724RefSeq WP_003439430.1

Clusters

CD-HIT memberships and selected cluster details for the current gene class

Selected clusterHKOC_0405625Run 6 · HK · 328 sequences
Representative sequenceGCF_000003215#QAC_RS0209445Use this link to inspect the representative gene detail.
PFAM architectureKdpD + DUF4118 + HisKA + HATPase_c4 domains in the representative PFAM annotation.

PFAM architecture for HKOC_0405625

Simplified PFAM architecture for HKOC_0405625

PFAM domain coverage: 494 / 900 aa (54.9%)

1 aa900 aa
KdpD: 22-230 aaKdpDDUF4118: 409-514 aaDUF4118HisKA: 676-743 aaHisKAHATPase_c: 788-898 aaHATPase_c
KdpDDUF4118HisKAHATPase_c
  • Simplified architecture: KdpD + DUF4118 + HisKA + HATPase_c
  • Raw architecture: KdpD[22-230] | DUF4118[409-514] | HisKA[676-743] | HATPase_c[788-898]
  • Domain count: 4
  • Matched identifier: HKOC_0405625
  • Positioned domains: KdpD 22-230 ; DUF4118 409-514 ; HisKA 676-743 ; HATPase_c 788-898
Cluster members and taxonomy
Visualization

Representative gene: GCF_000003215#QAC_RS0209445

Sankey plot built from the taxonomy of all members in the selected cluster.

Genome taxonomy

Unknown

Taxonomy recordUnknownTaxon ID 645 463 · GCF_000027105
AssemblyASM2710v1 · Chromosomehaploid
Genome composition4 191 339 bp · 29,0% GCClostridioides difficile R20291
Signal transduction countsGenes 108 · HK 51 · RR 57CheA 1 · PP 0
Ranked taxonomy7 ranked levels available
SuperkingdomBacteriaKingdomBacillatiPhylumBacillotaClassClostridiaOrderPeptostreptococcalesFamilyPeptostreptococcaceaeGenusClostridioides
Lineage path7 lineage nodes
1Bacteria2Bacillati3Bacillota4Clostridia5Peptostreptococcales6Peptostreptococcaceae7Clostridioides

Related genes

Preview from the same derived genome key