1 GAF#1
226-347 aa · 122 aa · 21.6% of protein
Raw token
GAF:226:0.0000195:347:134:133P2CS-Web
Two-component systems, rebuilt for exploration
Gene detail
ECSP_RS17345
Histidine kinase, Classic
Escherichia coli O157:H7 str. TW14359 · GCF_000022225
ClassHKTypeClassicLength565 aaTM0ValidatedNoCompleteYesContextpaired
Gene IDGCF_000022225#ECSP_RS17345Stable P2CS identifier used across views.
GenomeGCF_000022225Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Domain signature
Compact overview inferred from the domain field
GAFHis_kinaseHATPase_c
Protein length565 aaLength used to scale native and Biotite-like views.
Annotated domains33 with usable coordinates.
Domain coverage298 / 565 aa (52.7%)Merged over positioned domains only.
Domain description1 GAF,1 His_kinase,1 HATPase_cSummary string stored in the genes table.
Signal peptideUnavailableNo TMPRED prediction file matched this gene.
Transmembrane helicesUnavailableConfigure [protein_features] tmpred_root_dir to enable this annotation.
Complete domain annotations
Native P2CS viewFrontend rendering from the parsed domain string and TMPRED protein features.
1 aa565 aa
Domain-by-domain annotation3 items
2 His_kinase#2
359-438 aa · 80 aa · 14.2% of protein
Raw token
His_kinase:359:1.13e-31:438:81:803 HATPase_c#3
456-551 aa · 96 aa · 17.0% of protein
Raw token
HATPase_c:456:0.0000000000401:551:103:109- Raw architecture: GAF:226:0.0000195:347:134:133#His_kinase:359:1.13e-31:438:81:80#HATPase_c:456:0.0000000000401:551:103:109
- Domain description: 1 GAF,1 His_kinase,1 HATPase_c
- TM description: N/A
- TMPRED source: No TMPRED file loaded
- TMPRED segments: N/A
- Complete: Yes
Context mapping
Resolved via p2cs_tcs_context.db when a locus tag match exists
Context labelpairedGCF_000022225::NC_013008.1::G00023
Group size22 locus tags listed below.
HK / RR1 / 1Counts resolved for the local TCS neighborhood.
Context span3285792-3288238Genomic interval covered by the local TCS group.
Identifiers
Old locus tagECSP_3330RefSeq proteinWP_000544359.1
Context group ID
GCF_000022225::NC_013008.1::G00023Context members
ECSP_RS17345ECSP_RS17350
Partner locus tags
ECSP_RS17345ECSP_RS17350
Partner old locus tags
ECSP_3330ECSP_3331
Partner protein IDs
External references
Resolved via p2cs_annexes.db when the RefSeq protein is present in the annex table
RefSeqWP_000544359.1Primary protein accession used for annex mappings.
UniProt accessionA0AAV3H631Primary UniProt accession resolved in the annex database.
UniProt IDA0AAV3H631_ECOLXDisplay identifier provided by UniProt.
GO / PubMed4 / 0Unique GO terms and literature references available below.
Reference hubs
Genomic coordinates
Resolved via p2cs_tcs_context.db when the current locus tag is present in the local context table
Current locus tagECSP_RS17345Primary locus identifier stored in the genes table.
Old locus tagECSP_3330Legacy locus tag recovered from the local context mapping.
Contig / repliconNC_013008.1Sequence record reported by the local genomic context database.
Genomic interval3 285 792-3 287 489 nt1 698 nt · Forward (+)
StrandForward (+)Strand sign follows the local context database convention.
Local TCS group span3 285 792-3 288 238 ntGCF_000022225::NC_013008.1::G00023
Quick actions
Local neighborhood
Graphical neighborhood resolved from the local TCS context group on the current contig
GCF_000022225::NC_013008.1::G00023Graphic view
Compact keeps a quick overview. Biotite-like switches to a coordinate-aware biological layout with strand and zoom.
Context labelpairedNeighborhood members are ordered by genomic coordinates.
Contig / repliconNC_013008.1All displayed genes belong to this local TCS context.
Neighborhood span3 285 792-3 288 238 nt2 447 nt
Members21 current focus gene
Local TCS group mapArrow direction follows strand. The current gene is highlighted with a stronger outline.
3 285 792 nt3 288 238 nt
Neighborhood gene cards
2 genes in the current local neighborhood.
ECSP_RS17345GCF_000022225#ECSP_RS17345
HKClassicCurrent focus
3 285 792-3 287 489 nt · Forward (+)
ECSP_RS17350GCF_000022225#ECSP_RS17350
RRLytTR
3 287 504-3 288 238 nt · Forward (+)
Clusters
CD-HIT memberships and selected cluster details for the current gene class
Available memberships1 cluster
Representative sequenceGCF_002769135#CU508_RS05230Use this link to inspect the representative gene detail.
PFAM architecture5TM-5TMR_LYT + GAF + His_kinase + HATPase_c4 domains in the representative PFAM annotation.
PFAM architecture for HKOC_1208190
Simplified PFAM architecture for HKOC_1208190
PFAM domain coverage: 461 / 571 aa (80.7%)
1 aa571 aa
5TM-5TMR_LYTGAFHis_kinaseHATPase_c
- Simplified architecture: 5TM-5TMR_LYT + GAF + His_kinase + HATPase_c
- Raw architecture: 5TM-5TMR_LYT[28-192] | GAF[226-343] | His_kinase[359-438] | HATPase_c[456-553]
- Domain count: 4
- Matched identifier: HKOC_1208190
- Positioned domains: 5TM-5TMR_LYT 28-192 ; GAF 226-343 ; His_kinase 359-438 ; HATPase_c 456-553
Cluster members and taxonomy
Representative gene: GCF_002769135#CU508_RS05230
Sankey plot built from the taxonomy of all members in the selected cluster.
Genome taxonomy
Unknown
Taxonomy recordUnknownTaxon ID 544 404 · GCF_000022225
AssemblyASM2222v1 · Complete Genomehaploid
Genome composition5 622 737 bp · 50,5% GCEscherichia coli O157:H7 str. TW14359
Signal transduction countsGenes 64 · HK 31 · RR 33CheA 1 · PP 0
Ranked taxonomy7 ranked levels available
SuperkingdomBacteriaKingdomPseudomonadatiPhylumPseudomonadotaClassGammaproteobacteriaOrderEnterobacteralesFamilyEnterobacteriaceaeGenusEscherichia
Lineage path7 lineage nodes
1Bacteria2Pseudomonadati3Pseudomonadota4Gammaproteobacteria5Enterobacterales6Enterobacteriaceae7Escherichia
Related genes
Preview from the same derived genome key