P2CS-Web

Two-component systems, rebuilt for exploration

Gene detail

ECB_RS11995

Histidine kinase, Unorthodox

Escherichia coli B str. REL606 · GCF_000017985

Open genomeOpen selected clusterRefSeqUniProt
ClassHKTypeUnorthodoxLength1197 aaTM0ValidatedNoCompleteYesContextpaired
Gene IDGCF_000017985#ECB_RS11995Stable P2CS identifier used across views.
GenomeGCF_000017985Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Selected clusterHKOC_0161002Run 6 · 4258 sequences · id 100% · cov 80%
External referencesWP_001326970.1 · A0ABD7FKB4 · MIST4 ECB_RS11995RefSeq · UniProt · MIST4

Domain signature

Compact overview inferred from the domain field

PBPbHisKAHATPase_cResponse_regHpt
Protein length1197 aaLength used to scale native and Biotite-like views.
Annotated domains66 with usable coordinates.
Domain coverage797 / 1197 aa (66.6%)Merged over positioned domains only.
Domain description2 PBPb,1 HisKA,1 HATPase_c,1 Response_reg,1 HptSummary string stored in the genes table.
Signal peptideUnavailableNo TMPRED prediction file matched this gene.
Transmembrane helicesUnavailableConfigure [protein_features] tmpred_root_dir to enable this annotation.
Complete domain annotations
Domain view
NativeBiotite-like
Native P2CS viewFrontend rendering from the parsed domain string and TMPRED protein features.
1 aa1197 aa
PBPb: 73-276 aa (204 aa)1PBPb: 303-519 aa (217 aa)2HisKA: 711-777 aa (67 aa)3HATPase_c: 825-938 aa (114 aa)4Response_reg: 961-1070 aa (110 aa)5Hpt: 1104-1188 aa (85 aa)6
Domain-by-domain annotation6 items
1 PBPb#1
73-276 aa · 204 aa · 17.0% of protein
Raw tokenPBPb:73:0.00000000000000432:276:209:219
2 PBPb#2
303-519 aa · 217 aa · 18.1% of protein
Raw tokenPBPb:303:8.06e-40:519:224:219
3 HisKA#3
711-777 aa · 67 aa · 5.6% of protein
Raw tokenHisKA:711:2.14e-16:777:67:64
4 HATPase_c#4
825-938 aa · 114 aa · 9.5% of protein
Raw tokenHATPase_c:825:1.15e-31:938:114:109
5 Response_reg#5
961-1070 aa · 110 aa · 9.2% of protein
Raw tokenResponse_reg:961:1.25e-39:1070:110:111
6 Hpt#6
1104-1188 aa · 85 aa · 7.1% of protein
Raw tokenHpt:1104:0.0000000918:1188:85:84
  • Raw architecture: PBPb:73:0.00000000000000432:276:209:219#PBPb:303:8.06e-40:519:224:219#HisKA:711:2.14e-16:777:67:64#HATPase_c:825:1.15e-31:938:114:109#Response_reg:961:1.25e-39:1070:110:111#Hpt:1104:0.0000000918:1188:85:84
  • Domain description: 2 PBPb,1 HisKA,1 HATPase_c,1 Response_reg,1 Hpt
  • TM description: N/A
  • TMPRED source: No TMPRED file loaded
  • TMPRED segments: N/A
  • Complete: Yes

Context mapping

Resolved via p2cs_tcs_context.db when a locus tag match exists

Context labelpairedGCF_000017985::NC_012967.1::G00020
Group size22 locus tags listed below.
HK / RR1 / 1Counts resolved for the local TCS neighborhood.
Context span2417982-2422194Genomic interval covered by the local TCS group.
Identifiers
Old locus tagECB_02280RefSeq proteinWP_001326970.1
Context group IDGCF_000017985::NC_012967.1::G00020
Context members
ECB_RS11990ECB_RS11995
Partner locus tags
ECB_RS11990ECB_RS11995
Partner old locus tags
ECB_02279ECB_02280
Partner protein IDs
WP_000991370.1WP_001326970.1

External references

Resolved via p2cs_annexes.db when the RefSeq protein is present in the annex table

RefSeqWP_001326970.1Primary protein accession used for annex mappings.
UniProt accessionA0ABD7FKB4Primary UniProt accession resolved in the annex database.
UniProt IDA0ABD7FKB4_ECOLXDisplay identifier provided by UniProt.
GO / PubMed3 / 0Unique GO terms and literature references available below.
Reference hubs
Open RefSeqOpen UniProt accession
GO terms
GO:0005886GO:0005524GO:0000155

Genomic coordinates

Resolved via p2cs_tcs_context.db when the current locus tag is present in the local context table

Current locus tagECB_RS11995Primary locus identifier stored in the genes table.
Old locus tagECB_02280Legacy locus tag recovered from the local context mapping.
Contig / repliconNC_012967.1Sequence record reported by the local genomic context database.
Genomic interval2 418 601-2 422 194 nt3 594 nt · Forward (+)
StrandForward (+)Strand sign follows the local context database convention.
Local TCS group span2 417 982-2 422 194 ntGCF_000017985::NC_012967.1::G00020
Quick actions
Open genomeSearch genes in genome

Local neighborhood

Graphical neighborhood resolved from the local TCS context group on the current contig

GCF_000017985::NC_012967.1::G00020
Graphic view
CompactBiotite-like
Zoom
Full windowFocus gene

Compact keeps a quick overview. Biotite-like switches to a coordinate-aware biological layout with strand and zoom.

Context labelpairedNeighborhood members are ordered by genomic coordinates.
Contig / repliconNC_012967.1All displayed genes belong to this local TCS context.
Neighborhood span2 417 982-2 422 194 nt4 213 nt
Members21 current focus gene
Local TCS group mapArrow direction follows strand. The current gene is highlighted with a stronger outline.
2 417 982 nt2 422 194 nt
+-ECB_RS11990ECB_RS11995
Neighborhood gene cards

2 genes in the current local neighborhood.

ECB_RS11990GCF_000017985#ECB_RS11990
RRunclassified

2 417 982-2 418 596 nt · Forward (+)

Old locus ECB_02279RefSeq WP_000991370.1
Open gene
ECB_RS11995GCF_000017985#ECB_RS11995
HKUnorthodoxCurrent focus

2 418 601-2 422 194 nt · Forward (+)

Old locus ECB_02280RefSeq WP_001326970.1
Open current gene

Clusters

CD-HIT memberships and selected cluster details for the current gene class

Available memberships1 cluster
HKOC_0161002HK
Run 64258 sequencesid 100%cov 80%
PFAM SBP_bac_3 + SBP_bac_3 + HisKA + HATPase_c + Response_reg + Hpt
Representative GCF_000005845#b2370
Selected clusterHKOC_0161002Run 6 · HK · 4258 sequences
Representative sequenceGCF_000005845#b2370Use this link to inspect the representative gene detail.
PFAM architectureSBP_bac_3 + SBP_bac_3 + HisKA + HATPase_c + Response_reg + Hpt6 domains in the representative PFAM annotation.
Open in cluster searchOpen representative gene

PFAM architecture for HKOC_0161002

Simplified PFAM architecture for HKOC_0161002

PFAM domain coverage: 802 / 1197 aa (67.0%)

1 aa1197 aa
SBP_bac_3: 63-276 aaSBP_bac_3SBP_bac_3: 306-520 aaSBP_bac_3HisKA: 711-777 aaHisKAHATPase_c: 825-937 aaHATPase_cResponse_reg: 961-1070 aaResponse_regHpt: 1104-1186 aaHpt
SBP_bac_3SBP_bac_3HisKAHATPase_cResponse_regHpt
  • Simplified architecture: SBP_bac_3 + SBP_bac_3 + HisKA + HATPase_c + Response_reg + Hpt
  • Raw architecture: SBP_bac_3[63-276] | SBP_bac_3[306-520] | HisKA[711-777] | HATPase_c[825-937] | Response_reg[961-1070] | Hpt[1104-1186]
  • Domain count: 6
  • Matched identifier: HKOC_0161002
  • Positioned domains: SBP_bac_3 63-276 ; SBP_bac_3 306-520 ; HisKA 711-777 ; HATPase_c 825-937 ; Response_reg 961-1070 ; Hpt 1104-1186
Cluster members and taxonomy
Visualization
SankeyMember list

Representative gene: GCF_000005845#b2370

Sankey plot built from the taxonomy of all members in the selected cluster.

Genome taxonomy

Unknown

Taxonomy recordUnknownTaxon ID 413 997 · GCF_000017985
AssemblyASM1798v1 · Complete Genomehaploid
Genome composition4 629 812 bp · 51,0% GCEscherichia coli B str. REL606
Signal transduction countsGenes 58 · HK 28 · RR 30CheA 1 · PP 0
Ranked taxonomy7 ranked levels available
SuperkingdomBacteriaKingdomPseudomonadatiPhylumPseudomonadotaClassGammaproteobacteriaOrderEnterobacteralesFamilyEnterobacteriaceaeGenusEscherichia
Lineage path7 lineage nodes
1Bacteria2Pseudomonadati3Pseudomonadota4Gammaproteobacteria5Enterobacterales6Enterobacteriaceae7Escherichia
Open genomeSearch genes in genomeSearch HK genesNCBI assembly files

Related genes

Preview from the same derived genome key

10 preview genes

This panel keeps a short preview on the gene page. Use the genome search to inspect the complete list.

Search all genome genesSearch HK genes
ECB_RS02520GCF_000017985#ECB_RS02520
RRunclassified

RR gene found in the same genome-level preview.

Open gene
ECB_RS03070GCF_000017985#ECB_RS03070
RRunclassified

RR gene found in the same genome-level preview.

Open gene