1 HAMP#1
175-243 aa · 69 aa · 14.5% of protein
Raw token
HAMP:175:0.000000834:243:69:69P2CS-Web
Two-component systems, rebuilt for exploration
Gene detail
S_RS14545
Histidine kinase, Classic
Shigella flexneri 2a str. 2457T · GCF_000007405
ClassHKTypeClassicLength475 aaTM0ValidatedNoCompleteYesContextorphan
Gene IDGCF_000007405#S_RS14545Stable P2CS identifier used across views.
GenomeGCF_000007405Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Shigella
Domain signature
Compact overview inferred from the domain field
HAMPHisKAHATPase_c
Protein length475 aaLength used to scale native and Biotite-like views.
Annotated domains33 with usable coordinates.
Domain coverage245 / 475 aa (51.6%)Merged over positioned domains only.
Domain description1 HAMP,1 HisKA,1 HATPase_cSummary string stored in the genes table.
Signal peptideUnavailableNo TMPRED prediction file matched this gene.
Transmembrane helicesUnavailableConfigure [protein_features] tmpred_root_dir to enable this annotation.
Complete domain annotations
Native P2CS viewFrontend rendering from the parsed domain string and TMPRED protein features.
1 aa475 aa
Domain-by-domain annotation3 items
2 HisKA#2
249-316 aa · 68 aa · 14.3% of protein
Raw token
HisKA:249:0.0000000000000562:316:68:643 HATPase_c#3
362-469 aa · 108 aa · 22.7% of protein
Raw token
HATPase_c:362:1.13e-23:469:108:109- Raw architecture: HAMP:175:0.000000834:243:69:69#HisKA:249:0.0000000000000562:316:68:64#HATPase_c:362:1.13e-23:469:108:109
- Domain description: 1 HAMP,1 HisKA,1 HATPase_c
- TM description: N/A
- TMPRED source: No TMPRED file loaded
- TMPRED segments: N/A
- Complete: Yes
Context mapping
Resolved via p2cs_tcs_context.db when a locus tag match exists
Context labelorphanGCF_000007405::NC_004741.1::G00021
Group size11 locus tag listed below.
HK / RR1 / 0Counts resolved for the local TCS neighborhood.
Context span2668129-2669556Genomic interval covered by the local TCS group.
Identifiers
Old locus tagS2775%2CS_2775RefSeq proteinWP_005047325.1
Context group ID
GCF_000007405::NC_004741.1::G00021Context members
S_RS14545
Partner locus tags
S_RS14545
Partner old locus tags
S2775%2CS_2775
Partner protein IDs
External references
Resolved via p2cs_annexes.db when the RefSeq protein is present in the annex table
RefSeqWP_005047325.1Primary protein accession used for annex mappings.
UniProt accessionQ0T1W4Primary UniProt accession resolved in the annex database.
UniProt IDQ0T1W4_SHIF8Display identifier provided by UniProt.
GO / PubMed6 / 1Unique GO terms and literature references available below.
Reference hubs
PubMed
Genomic coordinates
Resolved via p2cs_tcs_context.db when the current locus tag is present in the local context table
Current locus tagS_RS14545Primary locus identifier stored in the genes table.
Old locus tagS2775%2CS_2775Legacy locus tag recovered from the local context mapping.
Contig / repliconNC_004741.1Sequence record reported by the local genomic context database.
Genomic interval2 668 129-2 669 556 nt1 428 nt · Reverse (-)
StrandReverse (-)Strand sign follows the local context database convention.
Local TCS group span2 668 129-2 669 556 ntGCF_000007405::NC_004741.1::G00021
Quick actions
Local neighborhood
Graphical neighborhood resolved from the local TCS context group on the current contig
GCF_000007405::NC_004741.1::G00021Graphic view
Compact keeps a quick overview. Biotite-like switches to a coordinate-aware biological layout with strand and zoom.
Context labelorphanNeighborhood members are ordered by genomic coordinates.
Contig / repliconNC_004741.1All displayed genes belong to this local TCS context.
Neighborhood span2 668 129-2 669 556 nt1 428 nt
Members11 current focus gene
Local TCS group mapArrow direction follows strand. The current gene is highlighted with a stronger outline.
2 668 129 nt2 669 556 nt
Neighborhood gene cards
1 gene in the current local neighborhood.
S_RS14545GCF_000007405#S_RS14545
HKClassicCurrent focus
2 668 129-2 669 556 nt · Reverse (-)
Clusters
CD-HIT memberships and selected cluster details for the current gene class
Available memberships1 cluster
Representative sequenceGCF_000007405#S_RS14545The current gene is the representative for this cluster.
PFAM architectureHisKA + HATPase_c2 domains in the representative PFAM annotation.
PFAM architecture for HKOC_1664339
Simplified PFAM architecture for HKOC_1664339
PFAM domain coverage: 176 / 475 aa (37.1%)
1 aa475 aa
HisKAHATPase_c
- Simplified architecture: HisKA + HATPase_c
- Raw architecture: HisKA[250-316] | HATPase_c[362-470]
- Domain count: 2
- Matched identifier: HKOC_1664339
- Positioned domains: HisKA 250-316 ; HATPase_c 362-470
Cluster members and taxonomy
Representative gene: GCF_000007405#S_RS14545
Sankey plot built from the taxonomy of all members in the selected cluster.
Genome taxonomy
Unknown
Taxonomy recordUnknownTaxon ID 198 215 · GCF_000007405
AssemblyASM740v1 · Complete Genomehaploid
Genome composition4 599 354 bp · 51,0% GCShigella flexneri 2a str. 2457T
Signal transduction countsGenes 52 · HK 24 · RR 28CheA 1 · PP 0
Ranked taxonomy7 ranked levels available
SuperkingdomBacteriaKingdomPseudomonadatiPhylumPseudomonadotaClassGammaproteobacteriaOrderEnterobacteralesFamilyEnterobacteriaceaeGenusShigella
Lineage path7 lineage nodes
1Bacteria2Pseudomonadati3Pseudomonadota4Gammaproteobacteria5Enterobacterales6Enterobacteriaceae7Shigella
Related genes
Preview from the same derived genome key