1 HisKA#1
469-534 aa · 66 aa · 7.0% of protein
Raw token
HisKA:469:2.77e-17:534:66:64P2CS-Web
Two-component systems, rebuilt for exploration
Gene detail
b2218
Histidine kinase, Hybrid
Escherichia coli str. K-12 substr. MG1655 · GCF_000005845
ClassHKTypeHybridLength949 aaTM0ValidatedNoCompleteYesContextorphan
Gene IDGCF_000005845#b2218Stable P2CS identifier used across views.
GenomeGCF_000005845Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Domain signature
Compact overview inferred from the domain field
HisKAHATPase_cResponse_reg
Protein length949 aaLength used to scale native and Biotite-like views.
Annotated domains33 with usable coordinates.
Domain coverage286 / 949 aa (30.1%)Merged over positioned domains only.
Domain description1 HisKA,1 HATPase_c,1 Response_regSummary string stored in the genes table.
Signal peptideUnavailableNo TMPRED prediction file matched this gene.
Transmembrane helicesUnavailableConfigure [protein_features] tmpred_root_dir to enable this annotation.
Complete domain annotations
Native P2CS viewFrontend rendering from the parsed domain string and TMPRED protein features.
1 aa949 aa
Domain-by-domain annotation3 items
2 HATPase_c#2
581-690 aa · 110 aa · 11.6% of protein
Raw token
HATPase_c:581:8.74e-39:690:110:1093 Response_reg#3
827-936 aa · 110 aa · 11.6% of protein
Raw token
Response_reg:827:3.75e-36:936:110:111- Raw architecture: HisKA:469:2.77e-17:534:66:64#HATPase_c:581:8.74e-39:690:110:109#Response_reg:827:3.75e-36:936:110:111
- Domain description: 1 HisKA,1 HATPase_c,1 Response_reg
- TM description: N/A
- TMPRED source: No TMPRED file loaded
- TMPRED segments: N/A
- Complete: Yes
Context mapping
Resolved via p2cs_tcs_context.db when a locus tag match exists
Context labelorphanGCF_000005845::NC_000913.3::G00020
Group size11 locus tag listed below.
HK / RR1 / 0Counts resolved for the local TCS neighborhood.
Context span2317027-2319876Genomic interval covered by the local TCS group.
Identifiers
Context group ID
GCF_000005845::NC_000913.3::G00020Context members
b2218
Partner locus tags
b2218
Partner protein IDs
External references
Resolved via p2cs_annexes.db when the RefSeq protein is present in the annex table
No UniProt / GO / PubMed mapping was found for NP_416722.2.
Genomic coordinates
Resolved via p2cs_tcs_context.db when the current locus tag is present in the local context table
Current locus tagb2218Primary locus identifier stored in the genes table.
Old locus tagUnavailableNo previous locus tag available for this gene.
Contig / repliconNC_000913.3Sequence record reported by the local genomic context database.
Genomic interval2 317 027-2 319 876 nt2 850 nt · Reverse (-)
StrandReverse (-)Strand sign follows the local context database convention.
Local TCS group span2 317 027-2 319 876 ntGCF_000005845::NC_000913.3::G00020
Quick actions
Local neighborhood
Graphical neighborhood resolved from the local TCS context group on the current contig
GCF_000005845::NC_000913.3::G00020Graphic view
Compact keeps a quick overview. Biotite-like switches to a coordinate-aware biological layout with strand and zoom.
Context labelorphanNeighborhood members are ordered by genomic coordinates.
Contig / repliconNC_000913.3All displayed genes belong to this local TCS context.
Neighborhood span2 317 027-2 319 876 nt2 850 nt
Members11 current focus gene
Local TCS group mapArrow direction follows strand. The current gene is highlighted with a stronger outline.
2 317 027 nt2 319 876 nt
Neighborhood gene cards
1 gene in the current local neighborhood.
b2218GCF_000005845#b2218
HKHybridCurrent focus
2 317 027-2 319 876 nt · Reverse (-)
Clusters
CD-HIT memberships and selected cluster details for the current gene class
Available memberships1 cluster
PFAM architectureHisKA + HATPase_c + RcsC + Response_reg4 domains in the representative PFAM annotation.
PFAM architecture for HKOC_0327670
Simplified PFAM architecture for HKOC_0327670
PFAM domain coverage: 376 / 949 aa (39.6%)
1 aa949 aa
HisKAHATPase_cRcsCResponse_reg
- Simplified architecture: HisKA + HATPase_c + RcsC + Response_reg
- Raw architecture: HisKA[470-534] | HATPase_c[581-690] | RcsC[709-799] | Response_reg[827-936]
- Domain count: 4
- Matched identifier: HKOC_0327670
- Positioned domains: HisKA 470-534 ; HATPase_c 581-690 ; RcsC 709-799 ; Response_reg 827-936
Cluster members and taxonomy
Representative gene: GCF_000005845#b2218
Sankey plot built from the taxonomy of all members in the selected cluster.
Genome taxonomy
Unknown
Taxonomy recordUnknownTaxon ID 511 145 · GCF_000005845
AssemblyASM584v2 · Complete Genomereference genome · haploid
Genome composition4 641 652 bp · 51,0% GCEscherichia coli str. K-12 substr. MG1655
Signal transduction countsGenes 63 · HK 31 · RR 32CheA 2 · PP 0
Ranked taxonomy7 ranked levels available
SuperkingdomBacteriaKingdomPseudomonadatiPhylumPseudomonadotaClassGammaproteobacteriaOrderEnterobacteralesFamilyEnterobacteriaceaeGenusEscherichia
Lineage path7 lineage nodes
1Bacteria2Pseudomonadati3Pseudomonadota4Gammaproteobacteria5Enterobacterales6Enterobacteriaceae7Escherichia
Related genes
Preview from the same derived genome key