CEA/DSV/IBeB/SBVMe/LEMIRE - P2CS Database Geitlerinema sp. PCC 7407

Gene name	P2CS description	Original description
Geitlerinema sp. PCC 7407 GEI7407_0085 (GI 428223545)	Histidine kinase, Hybrid 1 Response_reg, 1 HisKA_MA, 1 HATPase_c, Genomic Context	response regulator receiver sensor signal transduction histidine kinase
Geitlerinema sp. PCC 7407 GEI7407_0087 (GI 428223547)	Histidine kinase, Hybrid 2 GAF,1 HisKA,1 HATPase_c,1 Response_reg Genomic Context	GAF sensor hybrid histidine kinase
Geitlerinema sp. PCC 7407 GEI7407_0421 (GI 428223877)	Histidine kinase, Hybrid 2 Response_reg,2 GAF,1 HisKA,1 HATPase_c,1 CYCc Genomic Context	GAF sensor-containing adenylate/guanylate cyclase
Geitlerinema sp. PCC 7407 GEI7407_0524 (GI 428223979)	Histidine kinase, Classic 1 Cache_1,1 HAMP,1 HisKA,1 HATPase_c Genomic Context	integral membrane sensor signal transduction histidine kinase
Geitlerinema sp. PCC 7407 GEI7407_0625 (GI 428224078)	Histidine kinase, Classic 1 HisKA,1 HATPase_c Genomic Context	integral membrane sensor signal transduction histidine kinase
Geitlerinema sp. PCC 7407 GEI7407_0763 (GI 428224216)	Histidine kinase, Hybrid 1 Response_reg,2 GAF,1 HisKA,1 HATPase_c Genomic Context	multi-sensor signal transduction histidine kinase
Geitlerinema sp. PCC 7407 GEI7407_0764 (GI 428224217)	Histidine kinase, Unorthodox 1 GAF,1 HisKA,1 HATPase_c,2 Response_reg,1 Hpt Genomic Context	multi-sensor hybrid histidine kinase
Geitlerinema sp. PCC 7407 GEI7407_0812 (GI 428224265)	Histidine kinase, Classic 2 PAS,1 GAF,1 HisKA,1 HATPase_c Genomic Context	multi-sensor signal transduction histidine kinase
Geitlerinema sp. PCC 7407 GEI7407_0824 (GI 428224277)	Histidine kinase, Classic 1 HisKA,1 HATPase_c Genomic Context	histidine kinase
Geitlerinema sp. PCC 7407 GEI7407_0825 (GI 428224278)	Histidine kinase, Classic 1 HisKA_MA, 1 HATPase_c Genomic Context	histidine kinase
Geitlerinema sp. PCC 7407 GEI7407_0869 (GI 428224322)	Histidine kinase, Classic 1 PAS_4,1 GAF,1 HisKA,1 HATPase_c Genomic Context	GAF sensor signal transduction histidine kinase
Geitlerinema sp. PCC 7407 GEI7407_0973 (GI 428224426)	Histidine kinase, Classic 3 PAS_4,1 PAS_3,2 GAF,1 HisKA,1 HATPase_c Genomic Context	multi-sensor signal transduction histidine kinase
Geitlerinema sp. PCC 7407 GEI7407_0978 (GI 428224431)	Histidine kinase, Classic 1 PAS_4, 1 PAS_3, 1 HisKA_MA, 1 HATPase_c, Genomic Context	PAS/PAC sensor signal transduction histidine kinase
Geitlerinema sp. PCC 7407 GEI7407_1016 (GI 428224469)	Histidine kinase, Hybrid 1 GAF,3 PAS_3,1 PAS_4,3 PAS,1 HisKA,1 HATPase_c,1 Response_reg Genomic Context	multi-sensor hybrid histidine kinase
Geitlerinema sp. PCC 7407 GEI7407_1048 (GI 428224500)	Histidine kinase, Classic 1 PAS,1 PAS_3,2 GAF,1 HisKA,1 HATPase_c Genomic Context	multi-sensor signal transduction histidine kinase
Geitlerinema sp. PCC 7407 GEI7407_1110 (GI 428224562)	Histidine kinase, Classic 1 HisKA,1 HATPase_c Genomic Context	integral membrane sensor signal transduction histidine kinase
Geitlerinema sp. PCC 7407 GEI7407_1164 (GI 428224616)	Histidine kinase, Classic 1 HAMP,1 HisKA,1 HATPase_c Genomic Context	integral membrane sensor signal transduction histidine kinase
Geitlerinema sp. PCC 7407 GEI7407_1214 (GI 428224665)	Histidine kinase, Classic 1 GAF,1 HisKA,1 HATPase_c Genomic Context	GAF sensor signal transduction histidine kinase
Geitlerinema sp. PCC 7407 GEI7407_1233 (GI 428224683)	Histidine kinase, Classic 1 HAMP, 1 GAF, 1 HisKA_MA, 1 HATPase_c, Genomic Context	multi-sensor signal transduction histidine kinase
Geitlerinema sp. PCC 7407 GEI7407_1402 (GI 428224851)	Histidine kinase, Classic 1 Cache_1,1 HAMP,1 HisKA,1 HATPase_c Genomic Context	multi-sensor signal transduction histidine kinase
Geitlerinema sp. PCC 7407 GEI7407_1423 (GI 428224871)	Histidine kinase, Hybrid 2 HisKA,2 HATPase_c,1 Response_reg Genomic Context	PAS/PAC sensor hybrid histidine kinase
Geitlerinema sp. PCC 7407 GEI7407_1424 (GI 428224872)	Histidine kinase, Hybrid 1 GAF,2 PAS_4,3 PAS_3,1 HisKA,1 HATPase_c,1 Response_reg Genomic Context	multi-sensor hybrid histidine kinase
Geitlerinema sp. PCC 7407 GEI7407_1479 (GI 428224926)	Histidine kinase, Classic 1 PAS,2 PAS_4,2 GAF,1 HisKA,1 HATPase_c Genomic Context	multi-sensor signal transduction histidine kinase
Geitlerinema sp. PCC 7407 GEI7407_1480 (GI 428224927)	Histidine kinase, Classic 1 PAS_4,1 PAS,1 HisKA,1 HATPase_c Genomic Context	PAS/PAC sensor signal transduction histidine kinase
Geitlerinema sp. PCC 7407 GEI7407_1503 (GI 428224950)	Histidine kinase, Classic 2 GAF,1 HisKA,1 HATPase_c Genomic Context	GAF sensor signal transduction histidine kinase
Geitlerinema sp. PCC 7407 GEI7407_1505 (GI 428224952)	Histidine kinase, Unorthodox 1 CHASE2,1 HisKA,1 HATPase_c,2 Response_reg,1 Hpt Genomic Context	multi-sensor hybrid histidine kinase
Geitlerinema sp. PCC 7407 GEI7407_1518 (GI 428224965)	Histidine kinase, Classic 1 Pkinase,1 GAF,1 HisKA,1 HATPase_c Genomic Context	multi-sensor signal transduction multi-kinase
Geitlerinema sp. PCC 7407 GEI7407_1590 (GI 428225036)	Histidine kinase, Classic 1 HAMP,1 HisKA,1 HATPase_c Genomic Context	integral membrane sensor signal transduction histidine kinase
Geitlerinema sp. PCC 7407 GEI7407_1599 (GI 428225045)	Histidine kinase, Classic 1 GAF,1 HisKA,1 HATPase_c Genomic Context	GAF sensor signal transduction histidine kinase
Geitlerinema sp. PCC 7407 GEI7407_1641 (GI 428225087)	Histidine kinase, Unorthodox 1 CHASE,3 PAS,2 GAF,1 HisKA,1 HATPase_c,2 Response_reg,1 Hpt Genomic Context	multi-sensor hybrid histidine kinase
Geitlerinema sp. PCC 7407 GEI7407_1703 (GI 428225147)	Histidine kinase, Hybrid 3 MHYT,1 PAS,1 PAS_3,1 GAF,1 HisKA,1 HATPase_c,1 Response_reg Genomic Context	multi-sensor hybrid histidine kinase
Geitlerinema sp. PCC 7407 GEI7407_1711 (GI 428225155)	Histidine kinase, Classic 3 GAF,1 PAS,1 HisKA,1 HATPase_c Genomic Context	multi-sensor signal transduction histidine kinase
Geitlerinema sp. PCC 7407 GEI7407_1726 (GI 428225168)	Histidine kinase, Classic 1 HAMP,1 HisKA,1 HATPase_c Genomic Context	integral membrane sensor signal transduction histidine kinase
Geitlerinema sp. PCC 7407 GEI7407_1775 (GI 428225217)	Histidine kinase, Classic 1 Pkinase, 1 GAF, 1 HisKA_MA, 1 HATPase_c, Genomic Context	multi-sensor signal transduction multi-kinase
Geitlerinema sp. PCC 7407 GEI7407_1778 (GI 428225220)	Histidine kinase, Unorthodox 4 CBS,2 GAF,3 PAS_3,2 PAS_4,1 HisKA,1 HATPase_c,2 Response_reg,1 Hpt Genomic Context	multi-sensor hybrid histidine kinase
Geitlerinema sp. PCC 7407 GEI7407_1849 (GI 428225288)	Histidine kinase, Hybrid 1 Cache_1,1 HAMP,1 HisKA,1 HATPase_c,1 Response_reg Genomic Context	multi-sensor hybrid histidine kinase
Geitlerinema sp. PCC 7407 GEI7407_1856 (GI 428225295)	Histidine kinase, Classic 1 GAF,2 PAS_4,1 PAS,1 HisKA_3,1 HATPase_c Genomic Context	multi-sensor signal transduction histidine kinase
Geitlerinema sp. PCC 7407 GEI7407_1891 (GI 428225328)	Histidine kinase, Hybrid 1 Response_reg,2 GAF,1 HisKA,1 HATPase_c Genomic Context	multi-sensor signal transduction histidine kinase
Geitlerinema sp. PCC 7407 GEI7407_1895 (GI 428225332)	Histidine kinase, Classic 1 CHASE,1 HisKA,1 HATPase_c Genomic Context	histidine kinase
Geitlerinema sp. PCC 7407 GEI7407_1897 (GI 428225334)	Histidine kinase, Classic 2 GAF,1 HisKA,1 HATPase_c Genomic Context	GAF sensor signal transduction histidine kinase
Geitlerinema sp. PCC 7407 GEI7407_1901 (GI 428225338)	Histidine kinase, Hybrid 1 Response_reg,1 GAF,1 HisKA,1 HATPase_c Genomic Context	multi-sensor signal transduction histidine kinase
Geitlerinema sp. PCC 7407 GEI7407_1904 (GI 428225341)	Histidine kinase, Classic 4 PAS_4,1 PAS,2 PAS_3,1 HisKA,1 HATPase_c Genomic Context	PAS/PAC sensor signal transduction histidine kinase
Geitlerinema sp. PCC 7407 GEI7407_1958 (GI 428225394)	Histidine kinase, Classic 3 PAS_4,3 PAS_3,1 PAS,1 HisKA,1 HATPase_c Genomic Context	PAS/PAC sensor signal transduction histidine kinase
Geitlerinema sp. PCC 7407 GEI7407_1964 (GI 428225400)	Histidine kinase, Classic 1 PAS,1 HisKA,1 HATPase_c Genomic Context	multi-sensor signal transduction histidine kinase
Geitlerinema sp. PCC 7407 GEI7407_1994 (GI 428225430)	Histidine kinase, Hybrid 1 Response_reg,1 GAF,1 HisKA,1 HATPase_c Genomic Context	GAF sensor signal transduction histidine kinase
Geitlerinema sp. PCC 7407 GEI7407_1999 (GI 428225434)	Histidine kinase, Classic 2 GAF,1 HisKA,1 HATPase_c Genomic Context	GAF sensor signal transduction histidine kinase
Geitlerinema sp. PCC 7407 GEI7407_2013 (GI 428225448)	Histidine kinase, Hybrid 4 PAS_4,1 GAF,1 HisKA,2 HATPase_c,1 Response_reg,1 HisKA_2 Genomic Context	signal transduction histidine kinase
Geitlerinema sp. PCC 7407 GEI7407_2014 (GI 428225449)	Histidine kinase, Hybrid 1 Response_reg,1 PAS,1 HisKA,1 HATPase_c Genomic Context	PAS/PAC sensor hybrid histidine kinase
Geitlerinema sp. PCC 7407 GEI7407_2018 (GI 428225453)	Histidine kinase, Hybrid 2 Response_reg,2 PAS_3,1 HisKA,1 HATPase_c Genomic Context	multi-sensor hybrid histidine kinase
Geitlerinema sp. PCC 7407 GEI7407_2021 (GI 428225456)	Histidine kinase, Hybrid 1 CHASE3,1 HAMP,1 GAF,1 HisKA,1 HATPase_c,3 Response_reg Genomic Context	multi-sensor hybrid histidine kinase
Geitlerinema sp. PCC 7407 GEI7407_2022 (GI 428225457)	Histidine kinase, Classic 1 CHASE3,1 PAS_3,1 HisKA,1 HATPase_c Genomic Context	multi-sensor signal transduction histidine kinase
Geitlerinema sp. PCC 7407 GEI7407_2027 (GI 428225462)	Histidine kinase, Hybrid 1 GAF,1 PAS_4,2 PAS,2 PAS_3,1 HisKA,1 HATPase_c,1 Response_reg Genomic Context	PAS/PAC sensor hybrid histidine kinase
Geitlerinema sp. PCC 7407 GEI7407_2073 (GI 428225508)	Histidine kinase, Hybrid 1 Response_reg,1 HisKA,1 HATPase_c Genomic Context	response regulator receiver sensor signal transduction histidine kinase
Geitlerinema sp. PCC 7407 GEI7407_2074 (GI 428225509)	Histidine kinase, Hybrid 1 Cache_1,1 HisKA,1 HATPase_c,1 Response_reg Genomic Context	histidine kinase
Geitlerinema sp. PCC 7407 GEI7407_2081 (GI 428225516)	Histidine kinase, Classic 1 HisKA,1 HATPase_c Genomic Context	integral membrane sensor signal transduction histidine kinase
Geitlerinema sp. PCC 7407 GEI7407_2105 (GI 428225540)	Histidine kinase, Classic 4 CBS,3 PAS_4,1 PAS,2 GAF,1 HisKA,1 HATPase_c Genomic Context	multi-sensor signal transduction histidine kinase
Geitlerinema sp. PCC 7407 GEI7407_2127 (GI 428225562)	Histidine kinase, Hybrid 1 Response_reg,1 PAS,1 HisKA,1 HATPase_c Genomic Context	multi-sensor signal transduction histidine kinase
Geitlerinema sp. PCC 7407 GEI7407_2142 (GI 428225577)	Histidine kinase, Classic 1 PAS_4,1 HisKA,1 HATPase_c Genomic Context	multi-sensor signal transduction histidine kinase
Geitlerinema sp. PCC 7407 GEI7407_2167 (GI 428225602)	Histidine kinase, Hybrid 1 Response_reg, 1 HisKA_MA, 1 HATPase_c, Genomic Context	response regulator receiver sensor signal transduction histidine kinase
Geitlerinema sp. PCC 7407 GEI7407_2169 (GI 428225604)	Histidine kinase, CheA 1 Hpt,1 H-kinase_dim,1 HATPase_c,1 CheW,1 Response_reg Genomic Context	CheA signal transduction histidine kinase
Geitlerinema sp. PCC 7407 GEI7407_2257 (GI 428225687)	Histidine kinase, Classic 4 CBS,2 PAS_4,1 PAS_3,2 GAF,1 HisKA,1 HATPase_c Genomic Context	multi-sensor signal transduction histidine kinase
Geitlerinema sp. PCC 7407 GEI7407_2374 (GI 428225804)	Histidine kinase, Classic 2 GAF, 1 HisKA_MA, 1 HATPase_c, Genomic Context	GAF sensor signal transduction histidine kinase
Geitlerinema sp. PCC 7407 GEI7407_2393 (GI 428225823)	Histidine kinase, Hybrid 1 GAF,1 HisKA,1 HATPase_c,1 Response_reg Genomic Context	GAF sensor hybrid histidine kinase
Geitlerinema sp. PCC 7407 GEI7407_2472 (GI 428225902)	Histidine kinase, Classic 1 HisKA,1 HATPase_c Genomic Context	histidine kinase
Geitlerinema sp. PCC 7407 GEI7407_2476 (GI 428225906)	Histidine kinase, Hybrid 1 Response_reg,1 PAS_3,2 GAF,1 HisKA,1 HATPase_c Genomic Context	multi-sensor signal transduction histidine kinase
Geitlerinema sp. PCC 7407 GEI7407_2479 (GI 428225909)	Histidine kinase, Classic 2 PAS_3,1 HisKA,1 HATPase_c Genomic Context	PAS/PAC sensor signal transduction histidine kinase
Geitlerinema sp. PCC 7407 GEI7407_2518 (GI 428225948)	Histidine kinase, Hybrid 1 Response_reg, 1 HisKA_MA, 1 HATPase_c, Genomic Context	response regulator receiver sensor signal transduction histidine kinase
Geitlerinema sp. PCC 7407 GEI7407_2519 (GI 428225949)	Histidine kinase, Hybrid 1 MASE1,1 HisKA,1 HATPase_c,1 Response_reg Genomic Context	integral membrane sensor hybrid histidine kinase
Geitlerinema sp. PCC 7407 GEI7407_2535 (GI 428225965)	Histidine kinase, Hybrid 1 Response_reg,1 HisKA,1 HATPase_c Genomic Context	response regulator receiver sensor signal transduction histidine kinase
Geitlerinema sp. PCC 7407 GEI7407_2537 (GI 428225967)	Histidine kinase, Classic 1 GAF,1 PAS,1 HisKA,1 HATPase_c Genomic Context	multi-sensor signal transduction histidine kinase
Geitlerinema sp. PCC 7407 GEI7407_2542 (GI 428225972)	Histidine kinase, Classic 2 GAF, 1 HisKA_MA, 1 HATPase_c, Genomic Context	GAF domain-containing protein
Geitlerinema sp. PCC 7407 GEI7407_2584 (GI 428226014)	Histidine kinase, Classic 2 PAS_3,4 PAS_4,1 GAF,1 HisKA,1 HATPase_c Genomic Context	multi-sensor signal transduction histidine kinase
Geitlerinema sp. PCC 7407 GEI7407_2668 (GI 428226096)	Histidine kinase, CheA 1 Hpt,1 H-kinase_dim,1 HATPase_c,1 CheW,1 Response_reg Genomic Context	CheA signal transduction histidine kinase
Geitlerinema sp. PCC 7407 GEI7407_2700 (GI 428226128)	Histidine kinase, Hybrid 1 Response_reg,1 HisKA,1 HATPase_c Genomic Context	response regulator receiver sensor signal transduction histidine kinase
Geitlerinema sp. PCC 7407 GEI7407_2772 (GI 428226200)	Histidine kinase, Classic 1 PAS,1 HisKA,1 HATPase_c Genomic Context	PAS/PAC sensor signal transduction histidine kinase
Geitlerinema sp. PCC 7407 GEI7407_2891 (GI 428226317)	Histidine kinase, Classic 1 GAF,1 HisKA,1 HATPase_c Genomic Context	histidine kinase
Geitlerinema sp. PCC 7407 GEI7407_2987 (GI 428226412)	Histidine kinase, Hybrid 1 MASE1,3 PAS_4,2 PAS_3,1 PAS,1 HisKA,1 HATPase_c,1 Response_reg Genomic Context	multi-sensor hybrid histidine kinase
Geitlerinema sp. PCC 7407 GEI7407_3082 (GI 428226506)	Histidine kinase, Hybrid 1 CHASE,2 PAS_3,1 PAC,1 HisKA,1 HATPase_c,1 Response_reg Genomic Context	multi-sensor hybrid histidine kinase
Geitlerinema sp. PCC 7407 GEI7407_3128 (GI 428226551)	Histidine kinase, Classic 1 PAS_3,2 PAS,1 PAC,1 HisKA,1 HATPase_c Genomic Context	PAS/PAC sensor signal transduction histidine kinase
Geitlerinema sp. PCC 7407 GEI7407_3168 (GI 428226591)	Histidine kinase, Classic 1 Cache_1,1 HAMP,2 PAS_4,1 HisKA,1 HATPase_c Genomic Context	multi-sensor signal transduction histidine kinase
Geitlerinema sp. PCC 7407 GEI7407_3193 (GI 428226616)	Histidine kinase, Classic 1 S_TKc,1 Arch_ATPase,1 GAF,1 HisKA,1 HATPase_c Genomic Context	multi-sensor signal transduction multi-kinase
Geitlerinema sp. PCC 7407 GEI7407_3237 (GI 428226660)	Histidine kinase, Hybrid 1 HisKA,1 HATPase_c,1 Response_reg Genomic Context	histidine kinase
Geitlerinema sp. PCC 7407 GEI7407_3270 (GI 428226693)	Histidine kinase, Classic 2 GAF,1 HisKA,1 HATPase_c Genomic Context	GAF sensor signal transduction histidine kinase
Geitlerinema sp. PCC 7407 GEI7407_3307 (GI 428226730)	Histidine kinase, Classic 1 HisKA,1 HATPase_c Genomic Context	histidine kinase
Geitlerinema sp. PCC 7407 GEI7407_3375 (GI 428226797)	Histidine kinase, Classic 1 PAS,1 PAS_3,1 HisKA,1 HATPase_c Genomic Context	multi-sensor signal transduction histidine kinase
Geitlerinema sp. PCC 7407 GEI7407_3426 (GI 428226848)	Histidine kinase, Classic 2 GAF,1 HisKA,1 HATPase_c Genomic Context	GAF sensor signal transduction histidine kinase
Geitlerinema sp. PCC 7407 GEI7407_3540 (GI 428226962)	Histidine kinase, Classic 2 GAF,1 PAS_4,1 HisKA,1 HATPase_c Genomic Context	multi-sensor signal transduction histidine kinase
Geitlerinema sp. PCC 7407 GEI7407_3557 (GI 428226979)	Histidine kinase, Hybrid 1 Response_reg, 1 HisKA_MA, 1 HATPase_c, Genomic Context	response regulator receiver sensor signal transduction histidine kinase
Geitlerinema sp. PCC 7407 GEI7407_3558 (GI 428226980)	Histidine kinase, Unorthodox 1 CHASE3,1 PAS_3,2 PAS_4,1 HisKA,1 HATPase_c,2 Response_reg,1 Hpt Genomic Context	multi-sensor hybrid histidine kinase
Geitlerinema sp. PCC 7407 GEI7407_3564 (GI 428226986)	Histidine kinase, Classic 1 HisKA,1 HATPase_c Genomic Context	histidine kinase
Geitlerinema sp. PCC 7407 GEI7407_3663 (GI 428227085)	Histidine kinase, Classic 1 GAF,1 HisKA,1 HATPase_c Genomic Context	GAF sensor signal transduction histidine kinase
Geitlerinema sp. PCC 7407 GEI7407_3685 (GI 428227107)	Histidine kinase, Unorthodox 2 GAF,1 PAS_3,1 HisKA,1 HATPase_c,2 Response_reg,1 Hpt Genomic Context	multi-sensor hybrid histidine kinase
Geitlerinema sp. PCC 7407 GEI7407_3689 (GI 428227111)	Histidine kinase, CheA 1 Hpt,1 H-kinase_dim,1 HATPase_c,1 CheW,1 Response_reg Genomic Context	CheA signal transduction histidine kinase
Geitlerinema sp. PCC 7407 GEI7407_3692 (GI 428227114)	Histidine kinase, Classic 3 GAF,1 PAS_4,1 HisKA,1 HATPase_c Genomic Context	multi-sensor signal transduction histidine kinase
Geitlerinema sp. PCC 7407 GEI7407_3710 (GI 428227132)	Histidine kinase, Classic 1 HAMP,1 HisKA,1 HATPase_c Genomic Context	integral membrane sensor signal transduction histidine kinase
Geitlerinema sp. PCC 7407 GEI7407_3711 (GI 428227133)	Histidine kinase, Hybrid 2 PAS_3,1 HisKA,1 HATPase_c,1 Response_reg Genomic Context	multi-sensor hybrid histidine kinase
Geitlerinema sp. PCC 7407 GEI7407_3712 (GI 428227134)	Histidine kinase, Hybrid 1 Response_reg,1 HisKA,1 HATPase_c Genomic Context	response regulator receiver sensor signal transduction histidine kinase
Geitlerinema sp. PCC 7407 GEI7407_3829 (GI 428227251)	Histidine kinase, Classic 1 HAMP,1 PAS,1 HisKA,1 HATPase_c Genomic Context	multi-sensor signal transduction histidine kinase
Geitlerinema sp. PCC 7407 GEI7407_3849 (GI 428227271)	Histidine kinase, Classic 1 HisKA,1 HATPase_c Genomic Context	integral membrane sensor signal transduction histidine kinase