CEA/DSV/IBeB/SBVMe/LEMIRE - P2CS Database

P2CS is an integrated and comprehensive database of two-component system (TCS) signal transduction proteins, which contains a compilation of the TCS genes within completely sequenced genomes and metagenomes. It provides detailed annotation of each TCS gene including sequence features, functional domains, as well as chromosomal localization. Data can be downloaded for analysis and users can validate and add annotation to predicted TCS genes.

The database can be browsed and searched with a user-friendly web interface.

Quick access :

All TCS present in the database can be retrieved with :

P2CS Search menu for specific genome, gene or domain architecture search
P2CS Browse menu for all refined TCS annotation of each genome
P2CS Browse menu for all refined TCS annotation of each metagenome
P2CS Download menu for all TCS predicted in Excel Files of each genome

A complete documentation and a How-To section are accessible via the Documentation menu

See the P2CS publications for further details.

P2CS: a two-component system resource for prokaryotic signal transduction research

Barakat M, Ortet P, Jourlin-Castelli C, Ansaldi M, Mejean V, Whitworth DE.

BMC Genomics 2009, 10:315.
Abstract [ BMC ] [ PubMed ] Full text [ PDF ] [ HTML ]

P2CS: a database of prokaryotic two-component systems

Barakat M, Ortet P, Whitworth DE.

Nucleic Acids Research 2011, 39(suppl 1): D771-D776.
Abstract [ NAR ] [ PubMed ] Full text [ PDF ] [ HTML ]

P2TF (Predicted Prokaryotic Transcription Factors), a companion of P2CS, is now available at www.p2tf.org. P2TF, a database of Transcription Factor (TF) proteins, contains the TFs of all available bacterial and archaeal genomes, and 43 microbial metagenomes.

P2CS (Prokaryotic 2-Component Systems)

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Related databases and prediction tools :